Paralogue Annotation for SCN5A residue 773

Residue details

Gene: SCN5A
Reference Sequences: LRG: LRG_289, Ensembl variant: ENST00000333535 / ENSP00000328968
Amino Acid Position: 773
Reference Amino Acid: P - Proline
Protein Domain: TM Domain 2


Paralogue Variants mapped to SCN5A residue 773

No paralogue variants have been mapped to residue 773 for SCN5A.



SCN5ASEFEEMLQVGNLVFTGIFTAEMTFKIIALD>P<YYYFQQGWNIFDSIIVILSLMELGLSRMS-802
SCN1ADHFNNVLTVGNLVFTGIFTAEMFLKIIAMD>P<YYYFQEGWNIFDGFIVTLSLVELGLANVE-853
SCN2AEQFSSVLSVGNLVFTGIFTAEMFLKIIAMD>P<YYYFQEGWNIFDGFIVSLSLMELGLANVE-844
SCN3AEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD>P<YYYFQEGWNIFDGIIVSLSLMELGLSNVE-845
SCN4AEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD>P<YEYFQQGWNIFDSIIVTLSLVELGLANVQ-663
SCN7AKQTNTLLNIGNLVFIGIFTAEMIFKIIAMH>P<YGYFQVGWNIFDSMIVFHGLIELCLANVA-590
SCN8APQFEHVLAVGNLVFTGIFTAEMFLKLIAMD>P<YYYFQEGWNIFDGFIVSLSLMELSLADVE-838
SCN9AEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD>P<YEYFQVGWNIFDSLIVTLSLVELFLADVE-818
SCN10APTFEAMLQIGNIVFTIFFTAEMVFKIIAFD>P<YYYFQKKWNIFDCIIVTVSLLELGVAKKG-750
SCN11AASFEKMLNIGNLVFTSIFIAEMCLKIIALD>P<YHYFRRGWNIFDSIVALLSFADVMNCVLQK663
CACNA1AEWLSDFLYYAEFIFLGLFMSEMFIKMYGLG>T<RPYFHSSFNCFDCGVIIGSIFEVIWAVIKP573
CACNA1BRRLTTTLYFAEFVFLGLFLTEMSLKMYGLG>P<RSYFRSSFNCFDFGVIVGSVFEVVWAAIKP569
CACNA1CNWLTEVQDTANKALLALFTAEMLLKMYSLG>L<QAYFVSLFNRFDCFVVCGGILETILVETKI610
CACNA1DDWLTQIQDIANKVLLALFTCEMLVKMYSLG>L<QAYFVSLFNRFDCFVVCGGITETILVELEI629
CACNA1EQWLTHLLYYAEFLFLGLFLLEMSLKMYGMG>P<RLYFHSSFNCFDFGVTVGSIFEVVWAIFRP562
CACNA1FVWLTQIQEYANKVLLCLFTVEMLLKLYGLG>P<SAYVSSFFNRFDCFVVCGGILETTLVEVGA615
CACNA1GEELTNALEISNIVFTSLFALEMLLKLLVYG>P<FGYIKNPYNIFDGVIVVISVWEIVGQQGG-828
CACNA1HEELTNALEISNIVFTSMFALEMLLKLLACG>P<LGYIRNPYNIFDGIIVVISVWEIVGQADG-878
CACNA1IEELTNILEICNVVFTSMFALEMILKLAAFG>L<FDYLRNPYNIFDSIIVIISIWEIVGQADG-725
CACNA1SLWLTRLQDIANRVLLSLFTTEMLMKMYGLG>L<RQYFMSIFNRFDCFVVCSGILEILLVESGA518
cons                              > <                              

See full Alignment of Paralogues


Known Variants in SCN5A

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P773Sc.2317C>T Inherited ArrhythmiaBrSrs199473158SIFT: deleterious
Polyphen: probably damaging
ReportsInherited ArrhythmiaBrS An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010 7(1):33-46. 20129283