FOXO3 variants in ExAC

FOXO3 gene summary
FOXO3 variants in

The table below lists the FOXO3 variants found in the ExAC population database. Click on each variant for more details, including presence in the 1000 Genomes and Exome Sequencing Project databases, a breakdown by ethnic class and the variant's role in inherited cardiac disease. Use the form below to customise the variant selection. The table can be sorted by variant location, variant type or ExAC frequency.




No. Genomic coord.✝ Variant (CDS)▼ Variant (Protein) Variant Type▼ ExAC frequency▼Populations*
1. 108882706 c.295C>T p.R99W missense 0.03487230●●●●●●
2. 108985057 c.1021G>A p.A341T missense 0.00490220●●●●●●
3. 108882725 c.314G>T p.G105V missense 0.00125628●●●●●●
4. 108883043 c.621+11A>G splice site 0.00099713●●●●●●
5. 108882691 c.280C>T p.L94F missense 0.00022065●●●●●●
6. 108985151 c.1115T>C p.M372T missense 0.00018172●●●●●●
7. 108985280 c.1244C>T p.P415L missense 0.00015874●●●●●●
8. 108882677 c.266G>C p.G89A missense 0.00015523●●●●●●
9. 108985274 c.1238G>C p.S413T missense 0.00014994●●●●●●
10. 108985051 c.1015G>A p.D339N missense 0.00009926●●●●●●
11. 108984883 c.847G>A p.D283N missense 0.00008761●●●●●●
12. 108985124 c.1088C>T p.T363M missense 0.00006603●●●●●●
13. 108985265 c.1229G>A p.R410Q missense 0.00004994●●●●●●
14. 108882977 c.566G>A p.R189H missense 0.00004299●●●●●●
15. 108985004 c.968G>A p.R323H missense 0.00003348●●●●●●
16. 108985366 c.1330C>T p.R444C missense 0.00002522●●●●●●
17. 108985361 c.1325C>T p.S442F missense 0.00002518●●●●●●
18. 108985003 c.967C>T p.R323C missense 0.00002513●●●●●●
19. 108984871 c.835G>A p.E279K missense 0.00001761●●●●●●
20. 108984827 c.791G>A p.R264H missense 0.00001739●●●●●●
21. 108984922 c.886A>G p.T296A missense 0.00001733●●●●●●
22. 108985321 c.1285T>A p.S429T missense 0.00001676●●●●●●
23. 108985334 c.1298C>T p.T433M missense 0.00001676●●●●●●
24. 108985321 c.1285T>C p.S429P missense 0.00001676●●●●●●
25. 108985319 c.1283G>A p.S428N missense 0.00001676●●●●●●
26. 108985322 c.1286C>A p.S429Y missense 0.00001676●●●●●●
27. 108985342 c.1306G>A p.G436R missense 0.00001675●●●●●●
28. 108985298 c.1262C>T p.S421L missense 0.00001675●●●●●●
29. 108985220 c.1184C>T p.T395M missense 0.00001661●●●●●●
30. 108985042 c.1006G>T p.V336F missense 0.00001655●●●●●●
31. 108985195 c.1159A>T p.M387L missense 0.00001654●●●●●●
32. 108985063 c.1027C>G p.L343V missense 0.00001653●●●●●●
33. 108985118 c.1082C>T p.P361L missense 0.00001651●●●●●●
34. 108985118 c.1082C>G p.P361R missense 0.00001651●●●●●●
35. 108882914 c.503G>A p.R168H missense 0.00000923●●●●●●
36. 108984880 c.844_846delGAC p.Asp282del inframe 0.00000877●●●●●●
37. 108984862 c.826A>G p.T276A missense 0.00000876●●●●●●
38. 108984898 c.862C>T p.L288F missense 0.00000871●●●●●●
39. 108984841 c.805_807delAAG p.Lys269del inframe 0.00000870●●●●●●
40. 108984818 c.782C>T p.T261I missense 0.00000870●●●●●●
41. 108984832 c.796C>T p.R266C missense 0.00000870●●●●●●
42. 108984826 c.790C>T p.R264C missense 0.00000870●●●●●●
43. 108984947 c.911A>T p.D304V missense 0.00000864●●●●●●
44. 108882976 c.565C>T p.R189C missense 0.00000860●●●●●●
45. 108882973 c.562G>C p.V188L missense 0.00000860●●●●●●
46. 108985427 c.1391A>G p.H464R missense 0.00000859●●●●●●
47. 108985367 c.1331G>A p.R444H missense 0.00000841●●●●●●
48. 108985354 c.1318C>A p.L440M missense 0.00000839●●●●●●
49. 108985336 c.1300G>A p.V434M missense 0.00000838●●●●●●
50. 108985316 c.1280C>T p.T427I missense 0.00000838●●●●●●
51. 108985322 c.1286C>G p.S429C missense 0.00000838●●●●●●
52. 108985315 c.1279A>G p.T427A missense 0.00000838●●●●●●
53. 108985273 c.1237A>G p.S413G missense 0.00000833●●●●●●
54. 108985268 c.1232G>T p.S411I missense 0.00000833●●●●●●
55. 108985253 c.1217G>A p.G406E missense 0.00000832●●●●●●
56. 108985231 c.1195T>A p.S399T missense 0.00000831●●●●●●
57. 108985018 c.982A>T p.M328L missense 0.00000831●●●●●●
58. 108985057 c.1021G>T p.A341S missense 0.00000827●●●●●●
59. 108985199 c.1163A>G p.D388G missense 0.00000827●●●●●●
60. 108985058 c.1022C>G p.A341G missense 0.00000827●●●●●●
61. 108985173 c.1137T>A p.N379K missense 0.00000827●●●●●●
62. 108985052 c.1016A>T p.D339V missense 0.00000827●●●●●●
63. 108985070 c.1034C>T p.P345L missense 0.00000826●●●●●●
64. 108985156 c.1120G>A p.G374S missense 0.00000826●●●●●●
65. 108985072 c.1036A>C p.M346L missense 0.00000826●●●●●●
66. 108985160 c.1124C>G p.T375S missense 0.00000826●●●●●●
67. 108985090 c.1054G>A p.A352T missense 0.00000826●●●●●●
68. 108985072 c.1036A>G p.M346V missense 0.00000826●●●●●●
69. 108985150 c.1114A>G p.M372V missense 0.00000826●●●●●●
70. 108985097 c.1061T>G p.L354R missense 0.00000826●●●●●●

* This highlights the relative frequency of the variant in the ExAC populations - Non-Finnish European, African, East Asian, South Asian, American and Finnish. Higher frequencies are denoted by darker shades of green, variants absent in a population are coloured light gray.

✝ Genomic coordinates refer to the GRCh37 release of the human genome.