HRAS variants in ExAC

HRAS gene summary
HRAS variants in

The table below lists the HRAS variants found in the ExAC population database. Click on each variant for more details, including presence in the 1000 Genomes and Exome Sequencing Project databases, a breakdown by ethnic class and the variant's role in inherited cardiac disease. Use the form below to customise the variant selection. The table can be sorted by variant location, variant type or ExAC frequency.




No. Genomic coord.✝ Variant (CDS)▼ Variant (Protein) Variant Type▼ ExAC frequency▼Populations*
1. 533799 c.257A>C p.N86T missense 0.00023154●●●●●●
2. 532686 c.520C>T p.P174S missense 0.00016814●●●●●●
3. 533618 c.291-6T>G splice site 0.00011567●●●●●●
4. 534312 c.11A>G p.Y4C missense 0.00005049●●●●●●
5. 532701 c.505C>T p.R169W missense 0.00004194●●●●●●
6. 532698 c.508A>T p.K170X nonsense 0.00003356●●●●●●
7. 533536 c.367C>T p.R123C missense 0.00003307●●●●●●
8. 532660 c.546G>A p.M182I missense 0.00002565●●●●●●
9. 532700 c.506G>A p.R169Q missense 0.00002517●●●●●●
10. 534259 c.64C>T p.Q22X nonsense 0.00002493●●●●●●
11. 533535 c.368G>C p.R123P missense 0.00002480●●●●●●
12. 532668 c.538G>A p.G180S missense 0.00001696●●●●●●
13. 534206 c.111+6C>T splice site 0.00001682●●●●●●
14. 532760 c.451-5C>G splice site 0.00001677●●●●●●
15. 532760 c.451-5C>T splice site 0.00001677●●●●●●
16. 532746 c.460G>A p.D154N missense 0.00001675●●●●●●
17. 532716 c.490C>T p.R164W missense 0.00001674●●●●●●
18. 532724 c.482G>A p.R161H missense 0.00001674●●●●●●
19. 534292 c.31G>A p.A11T missense 0.00001669●●●●●●
20. 533763 c.290+3G>T splice site 0.00001658●●●●●●
21. 533803 c.253A>G p.N85D missense 0.00001654●●●●●●
22. 533606 c.297G>T p.Q99H missense 0.00001652●●●●●●
23. 533620 c.291-8C>T splice site 0.00001652●●●●●●
24. 532633 c.*3C>T splice site 0.00000923●●●●●●
25. 532670 c.536C>T p.P179L missense 0.00000846●●●●●●
26. 532763 c.451-8T>C splice site 0.00000839●●●●●●
27. 532703 c.503T>C p.L168P missense 0.00000838●●●●●●
28. 532704 c.502C>G p.L168V missense 0.00000838●●●●●●
29. 532715 c.491G>C p.R164P missense 0.00000837●●●●●●
30. 532715 c.491G>A p.R164Q missense 0.00000837●●●●●●
31. 532725 c.481C>T p.R161C missense 0.00000837●●●●●●
32. 533951 c.112-7C>T splice site 0.00000830●●●●●●
33. 533483 c.420_423dupCTAC p.Ile142LeufsTer22 frameshift 0.00000829●●●●●●
34. 533477 c.426C>G p.I142M missense 0.00000829●●●●●●
35. 533491 c.412G>A p.G138S missense 0.00000829●●●●●●
36. 533485 c.418C>T p.P140S missense 0.00000829●●●●●●
37. 533944 c.112G>C p.D38H missense 0.00000829●●●●●●
38. 533511 c.392A>G p.Q131R missense 0.00000828●●●●●●
39. 533500 c.403C>T p.R135X nonsense 0.00000828●●●●●●
40. 533776 c.280C>T p.H94Y missense 0.00000828●●●●●●
41. 533505 c.398T>A p.L133H missense 0.00000828●●●●●●
42. 533496 c.407G>C p.S136T missense 0.00000828●●●●●●
43. 533509 c.394G>A p.D132N missense 0.00000828●●●●●●
44. 533512 c.391C>T p.Q131X nonsense 0.00000828●●●●●●
45. 533541 c.362C>T p.A121V missense 0.00000827●●●●●●
46. 533527 c.376G>C p.E126Q missense 0.00000827●●●●●●
47. 533813 c.243_244delGT p.Phe82CysfsTer9 frameshift 0.00000827●●●●●●
48. 533538 c.365C>T p.A122V missense 0.00000827●●●●●●
49. 533853 c.203G>A p.R68Q missense 0.00000826●●●●●●
50. 533621 c.291-9delA splice site 0.00000826●●●●●●
51. 533612 c.291G>A splice site 0.00000826●●●●●●
52. 533857 c.199A>G p.M67V missense 0.00000826●●●●●●
53. 533572 c.331A>G p.M111V missense 0.00000826●●●●●●
54. 533833 c.223G>A p.G75R missense 0.00000826●●●●●●
55. 533884 c.172A>C p.T58P missense 0.00000826●●●●●●
56. 533841 c.215T>G p.M72R missense 0.00000826●●●●●●
57. 533586 c.317C>T p.S106L missense 0.00000826●●●●●●

* This highlights the relative frequency of the variant in the ExAC populations - Non-Finnish European, African, East Asian, South Asian, American and Finnish. Higher frequencies are denoted by darker shades of green, variants absent in a population are coloured light gray.

✝ Genomic coordinates refer to the GRCh37 release of the human genome.