MYH6 missense variants in ExAC

MYH6 gene summary
MYH6 variants in DCM

The table below lists the MYH6 missense variants found in the ExAC population database. Click on each variant for more details, including presence in the 1000 Genomes and Exome Sequencing Project databases, a breakdown by ethnic class and the variant's role in inherited cardiac disease. Use the form below to customise the variant selection. The table can be sorted by variant location, variant type or ExAC frequency.




No. Genomic coord.✝ Variant (CDS)▼ Variant (Protein) Variant Type▼ ExAC frequency▼Populations*
1. 23861811 c.3302T>C p.V1101A missense 0.34609809●●●●●●
2. 23859610 c.3388G>A p.A1130T missense 0.10033088●●●●●●
3. 23876267 c.166G>A p.G56R missense 0.06979618●●●●●●
4. 23873940 c.622G>A p.D208N missense 0.00550374●●●●●●
5. 23858697 c.3883G>C p.E1295Q missense 0.00324531●●●●●●
6. 23862997 c.2806G>T p.A936S missense 0.00238856●●●●●●
7. 23868065 c.1763A>C p.D588A missense 0.00213337●●●●●●
8. 23857430 c.4293G>A p.M1431I missense 0.00174621●●●●●●
9. 23863383 c.2579G>A p.R860H missense 0.00166387●●●●●●
10. 23876347 c.86G>A p.R29Q missense 0.00149923●●●●●●
11. 23862646 c.3010G>T p.A1004S missense 0.00098013●●●●●●
12. 23871682 c.1132G>A p.G378S missense 0.00088192●●●●●●
13. 23866269 c.2071G>A p.V691I missense 0.00079097●●●●●●
14. 23871683 c.1131C>G p.D377E missense 0.00071705●●●●●●
15. 23876363 c.70C>A p.L24I missense 0.00070022●●●●●●
16. 23858107 c.4136C>T p.T1379M missense 0.00061789●●●●●●
17. 23862913 c.2890G>T p.A964S missense 0.00047771●●●●●●
18. 23862996 c.2807C>T p.A936V missense 0.00044477●●●●●●
19. 23872624 c.831G>T p.Q277H missense 0.00042011●●●●●●
20. 23855577 c.4906C>T p.R1636C missense 0.00042010●●●●●●
21. 23857530 c.4193G>A p.R1398Q missense 0.00038785●●●●●●
22. 23853806 c.5410C>A p.Q1804K missense 0.00037891●●●●●●
23. 23863348 c.2614C>T p.R872C missense 0.00032125●●●●●●
24. 23870085 c.1243G>A p.G415R missense 0.00027181●●●●●●
25. 23859490 c.3508G>A p.E1170K missense 0.00024932●●●●●●
26. 23874889 c.292G>A p.E98K missense 0.00023063●●●●●●
27. 23870076 c.1252G>A p.V418M missense 0.00023062●●●●●●
28. 23862177 c.3195G>C p.Q1065H missense 0.00023062●●●●●●
29. 23856793 c.4595G>T p.R1532L missense 0.00021420●●●●●●
30. 23871727 c.1087A>T p.M363L missense 0.00018947●●●●●●
31. 23857458 c.4265G>A p.R1422Q missense 0.00018945●●●●●●
32. 23855779 c.4704C>A p.N1568K missense 0.00018189●●●●●●
33. 23853725 c.5491G>A p.E1831K missense 0.00018132●●●●●●
34. 23856987 c.4505G>A p.R1502Q missense 0.00018124●●●●●●
35. 23858648 c.3932C>T p.T1311I missense 0.00018120●●●●●●
36. 23858216 c.4027G>A p.D1343N missense 0.00017438●●●●●●
37. 23872631 c.824T>A p.I275N missense 0.00017299●●●●●●
38. 23858263 c.3980C>T p.A1327V missense 0.00016994●●●●●●
39. 23870174 c.1154C>T p.S385L missense 0.00016519●●●●●●
40. 23868075 c.1753G>A p.G585S missense 0.00015650●●●●●●
41. 23863498 c.2464G>A p.A822T missense 0.00014849●●●●●●
42. 23855280 c.5020G>A p.A1674T missense 0.00014834●●●●●●
43. 23854213 c.5201C>T p.S1734L missense 0.00014826●●●●●●
44. 23862208 c.3164G>A p.R1055Q missense 0.00014002●●●●●●
45. 23858255 c.3988G>A p.A1330T missense 0.00013190●●●●●●
46. 23873951 c.611G>A p.R204H missense 0.00013180●●●●●●
47. 23855223 c.5077G>A p.V1693M missense 0.00012365●●●●●●
48. 23852450 c.5645G>A p.R1882H missense 0.00012360●●●●●●
49. 23857459 c.4264C>T p.R1422W missense 0.00012355●●●●●●
50. 23858713 c.3867G>T p.L1289F missense 0.00011531●●●●●●
51. 23874936 c.245C>T p.P82L missense 0.00011531●●●●●●
52. 23876366 c.67C>T p.R23C missense 0.00010709●●●●●●
53. 23870001 c.1327C>T p.R443C missense 0.00010708●●●●●●
54. 23869992 c.1336G>A p.A446T missense 0.00010708●●●●●●
55. 23862142 c.3230A>T p.Q1077L missense 0.00010707●●●●●●
56. 23856794 c.4594C>T p.R1532C missense 0.00009886●●●●●●
57. 23867943 c.1885G>A p.D629N missense 0.00009885●●●●●●
58. 23874503 c.431G>T p.G144V missense 0.00009884●●●●●●
59. 23858687 c.3893C>T p.A1298V missense 0.00009061●●●●●●
60. 23876318 c.115G>A p.V39M missense 0.00009061●●●●●●
61. 23851741 c.5692T>C p.F1898L missense 0.00009060●●●●●●
62. 23862173 c.3199A>G p.S1067G missense 0.00009060●●●●●●
63. 23859651 c.3347G>A p.R1116H missense 0.00008985●●●●●●
64. 23855817 c.4666G>A p.E1556K missense 0.00008390●●●●●●
65. 23853697 c.5519A>G p.K1840R missense 0.00008245●●●●●●
66. 23853923 c.5293G>A p.A1765T missense 0.00008245●●●●●●
67. 23866227 c.2113C>T p.R705C missense 0.00008241●●●●●●
68. 23852468 c.5627A>G p.K1876R missense 0.00008241●●●●●●
69. 23853757 c.5459G>A p.R1820Q missense 0.00008238●●●●●●
70. 23870000 c.1328G>A p.R443H missense 0.00008237●●●●●●
71. 23862194 c.3178G>A p.D1060N missense 0.00008237●●●●●●
72. 23863387 c.2575G>T p.G859W missense 0.00008237●●●●●●
73. 23871807 c.1007C>G p.A336G missense 0.00007421●●●●●●
74. 23865539 c.2383C>T p.R795W missense 0.00007421●●●●●●
75. 23858877 c.3784C>T p.R1262C missense 0.00007414●●●●●●
76. 23874525 c.409G>A p.E137K missense 0.00007414●●●●●●
77. 23855711 c.4772A>G p.N1591S missense 0.00007413●●●●●●
78. 23867960 c.1868C>T p.S623F missense 0.00007413●●●●●●
79. 23869560 c.1486G>A p.V496M missense 0.00007413●●●●●●
80. 23853676 c.5540G>A p.R1847Q missense 0.00006599●●●●●●
81. 23866253 c.2087G>A p.R696H missense 0.00006591●●●●●●
82. 23876272 c.161G>A p.R54Q missense 0.00006591●●●●●●
83. 23857395 c.4328C>A p.A1443D missense 0.00006590●●●●●●
84. 23853758 c.5458C>T p.R1820W missense 0.00006590●●●●●●
85. 23863351 c.2611C>T p.R871C missense 0.00006590●●●●●●
86. 23870067 c.1261G>A p.V421M missense 0.00006589●●●●●●
87. 23870084 c.1244G>C p.G415A missense 0.00006589●●●●●●
88. 23859652 c.3346C>A p.R1116S missense 0.00006301●●●●●●
89. 23865569 c.2353C>T p.R785C missense 0.00005780●●●●●●
90. 23871926 c.982G>A p.E328K missense 0.00005778●●●●●●
91. 23852501 c.5594G>A p.R1865Q missense 0.00005774●●●●●●
92. 23855205 c.5095C>T p.R1699W missense 0.00005771●●●●●●
93. 23876356 c.77C>G p.A26G missense 0.00005767●●●●●●
94. 23855736 c.4747G>A p.E1583K missense 0.00005767●●●●●●
95. 23865989 c.2206C>A p.Q736K missense 0.00005766●●●●●●
96. 23857423 c.4300G>A p.V1434I missense 0.00005766●●●●●●
97. 23858853 c.3808C>T p.R1270C missense 0.00005766●●●●●●
98. 23855661 c.4822C>T p.R1608C missense 0.00005766●●●●●●
99. 23853868 c.5348G>A p.R1783H missense 0.00005766●●●●●●
100. 23862975 c.2828G>A p.R943H missense 0.00005765●●●●●●
101. 23865616 c.2306C>T p.A769V missense 0.00004998●●●●●●
102. 23855199 c.5101C>T p.R1701W missense 0.00004948●●●●●●
103. 23855301 c.4999G>A p.D1667N missense 0.00004946●●●●●●
104. 23853731 c.5485G>C p.E1829Q missense 0.00004945●●●●●●
105. 23857492 c.4231G>A p.A1411T missense 0.00004943●●●●●●
106. 23858903 c.3758C>T p.T1253M missense 0.00004943●●●●●●
107. 23857507 c.4216G>A p.V1406M missense 0.00004943●●●●●●
108. 23874868 c.313C>A p.L105I missense 0.00004943●●●●●●
109. 23871766 c.1048G>A p.V350I missense 0.00004943●●●●●●
110. 23868200 c.1628A>G p.K543R missense 0.00004942●●●●●●
111. 23869981 c.1347G>T p.E449D missense 0.00004942●●●●●●
112. 23863087 c.2716C>T p.R906C missense 0.00004942●●●●●●
113. 23859652 c.3346C>T p.R1116C missense 0.00004501●●●●●●
114. 23872967 c.756C>G p.H252Q missense 0.00004259●●●●●●
115. 23855331 c.4969A>G p.I1657V missense 0.00004125●●●●●●
116. 23855760 c.4723G>A p.E1575K missense 0.00004124●●●●●●
117. 23858161 c.4082G>A p.R1361H missense 0.00004123●●●●●●
118. 23853703 c.5513C>T p.S1838L missense 0.00004122●●●●●●
119. 23858159 c.4084G>A p.V1362I missense 0.00004122●●●●●●
120. 23865523 c.2399G>A p.R800H missense 0.00004121●●●●●●
121. 23852453 c.5642A>G p.K1881R missense 0.00004120●●●●●●
122. 23858874 c.3787G>A p.V1263M missense 0.00004119●●●●●●
123. 23863422 c.2540C>T p.T847M missense 0.00004119●●●●●●
124. 23874978 c.203C>T p.T68M missense 0.00004119●●●●●●
125. 23858602 c.3978G>C p.K1326N missense 0.00004119●●●●●●
126. 23874877 c.304C>A p.L102I missense 0.00004119●●●●●●
127. 23855655 c.4828C>T p.R1610C missense 0.00004118●●●●●●
128. 23874459 c.475G>A p.D159N missense 0.00004118●●●●●●
129. 23858708 c.3872G>A p.R1291Q missense 0.00004118●●●●●●
130. 23858666 c.3914G>A p.R1305Q missense 0.00004118●●●●●●
131. 23851743 c.5690A>G p.K1897R missense 0.00004118●●●●●●
132. 23862691 c.2965G>A p.E989K missense 0.00004118●●●●●●
133. 23862976 c.2827C>T p.R943C missense 0.00004118●●●●●●
134. 23862152 c.3220G>A p.D1074N missense 0.00004118●●●●●●
135. 23858207 c.4036C>T p.R1346W missense 0.00003315●●●●●●
136. 23855163 c.5137G>A p.E1713K missense 0.00003304●●●●●●
137. 23863522 c.2440C>A p.L814M missense 0.00003304●●●●●●
138. 23857531 c.4192C>T p.R1398W missense 0.00003302●●●●●●
139. 23865556 c.2366G>A p.R789H missense 0.00003301●●●●●●
140. 23865538 c.2384G>A p.R795Q missense 0.00003298●●●●●●
141. 23871675 c.1139A>C p.E380A missense 0.00003298●●●●●●
142. 23855756 c.4727G>A p.R1576Q missense 0.00003298●●●●●●
143. 23853715 c.5501G>A p.R1834H missense 0.00003297●●●●●●
144. 23853710 c.5506G>A p.A1836T missense 0.00003297●●●●●●
145. 23857516 c.4207G>A p.E1403K missense 0.00003296●●●●●●
146. 23866242 c.2098G>A p.V700M missense 0.00003296●●●●●●
147. 23871706 c.1108C>T p.R370W missense 0.00003296●●●●●●
148. 23863081 c.2722G>A p.D908N missense 0.00003295●●●●●●
149. 23862667 c.2989G>C p.E997Q missense 0.00003295●●●●●●
150. 23858102 c.4141G>A p.A1381T missense 0.00003295●●●●●●
151. 23855685 c.4798C>A p.Q1600K missense 0.00003295●●●●●●
152. 23863086 c.2717G>A p.R906H missense 0.00003295●●●●●●
153. 23865497 c.2425C>T p.R809C missense 0.00003295●●●●●●
154. 23858808 c.3853G>A p.E1285K missense 0.00003295●●●●●●
155. 23863347 c.2615G>A p.R872H missense 0.00003295●●●●●●
156. 23857416 c.4307G>A p.R1436H missense 0.00003295●●●●●●
157. 23865937 c.2258T>C p.I753T missense 0.00003295●●●●●●
158. 23851738 c.5695C>T p.R1899C missense 0.00003295●●●●●●
159. 23851739 c.5694C>G p.F1898L missense 0.00003295●●●●●●
160. 23853880 c.5336C>A p.A1779D missense 0.00003295●●●●●●
161. 23868125 c.1703G>A p.R568H missense 0.00003295●●●●●●
162. 23854136 c.5278G>A p.A1760T missense 0.00003295●●●●●●
163. 23863362 c.2600A>G p.K867R missense 0.00003295●●●●●●
164. 23855654 c.4829G>A p.R1610H missense 0.00003295●●●●●●
165. 23857417 c.4306C>T p.R1436C missense 0.00003295●●●●●●
166. 23859615 c.3383G>A p.R1128H missense 0.00002794●●●●●●
167. 23859484 c.3514G>A p.E1172K missense 0.00002561●●●●●●
168. 23871967 c.941T>C p.V314A missense 0.00002482●●●●●●
169. 23855159 c.5141G>A p.R1714Q missense 0.00002480●●●●●●
170. 23870172 c.1156G>A p.A386T missense 0.00002477●●●●●●
171. 23871947 c.961G>A p.V321M missense 0.00002477●●●●●●
172. 23855770 c.4713G>T p.K1571N missense 0.00002477●●●●●●
173. 23871932 c.976G>A p.D326N missense 0.00002476●●●●●●
174. 23865559 c.2363C>T p.T788M missense 0.00002476●●●●●●
175. 23852502 c.5593C>T p.R1865W missense 0.00002475●●●●●●
176. 23855198 c.5102G>A p.R1701Q missense 0.00002474●●●●●●
177. 23855310 c.4990C>T p.R1664C missense 0.00002473●●●●●●
178. 23871799 c.1015G>A p.V339M missense 0.00002473●●●●●●
179. 23855298 c.5002G>A p.D1668N missense 0.00002473●●●●●●
180. 23873927 c.635C>T p.A212V missense 0.00002473●●●●●●
181. 23865524 c.2398C>T p.R800C missense 0.00002473●●●●●●
182. 23866780 c.1934C>T p.S645F missense 0.00002473●●●●●●
183. 23855267 c.5033G>A p.R1678Q missense 0.00002472●●●●●●
184. 23866455 c.1974C>A p.N658K missense 0.00002472●●●●●●
185. 23855268 c.5032C>T p.R1678W missense 0.00002472●●●●●●
186. 23865521 c.2401A>G p.I801V missense 0.00002472●●●●●●
187. 23852439 c.5656G>A p.E1886K missense 0.00002472●●●●●●
188. 23874453 c.481G>A p.A161T missense 0.00002471●●●●●●
189. 23858859 c.3802G>T p.A1268S missense 0.00002471●●●●●●
190. 23863387 c.2575G>A p.G859R missense 0.00002471●●●●●●
191. 23862583 c.3073T>A p.S1025T missense 0.00002471●●●●●●
192. 23854154 c.5260G>A p.E1754K missense 0.00002471●●●●●●
193. 23876273 c.160C>T p.R54W missense 0.00002471●●●●●●
194. 23876333 c.100C>T p.R34C missense 0.00002471●●●●●●
195. 23862976 c.2827C>A p.R943S missense 0.00002471●●●●●●
196. 23873528 c.712C>T p.R238W missense 0.00002471●●●●●●
197. 23866022 c.2173C>T p.R725C missense 0.00002471●●●●●●
198. 23855714 c.4769G>A p.R1590H missense 0.00002471●●●●●●
199. 23869554 c.1492G>A p.E498K missense 0.00002471●●●●●●
200. 23851702 c.5731C>T p.R1911W missense 0.00002471●●●●●●
201. 23866276 c.2064C>A p.N688K missense 0.00002471●●●●●●
202. 23856793 c.4595G>A p.R1532H missense 0.00002471●●●●●●
203. 23862568 c.3088G>C p.E1030Q missense 0.00002471●●●●●●
204. 23874530 c.404A>G p.N135S missense 0.00002471●●●●●●
205. 23851727 c.5706G>T p.Q1902H missense 0.00002471●●●●●●
206. 23868126 c.1702C>T p.R568C missense 0.00002471●●●●●●
207. 23855609 c.4874A>G p.N1625S missense 0.00002471●●●●●●
208. 23873561 c.679G>A p.A227T missense 0.00002471●●●●●●
209. 23855583 c.4900G>A p.A1634T missense 0.00002471●●●●●●
210. 23861812 c.3301G>A p.V1101M missense 0.00002471●●●●●●
211. 23861814 c.3299A>T p.Q1100L missense 0.00002471●●●●●●
212. 23871726 c.1088T>C p.M363T missense 0.00002471●●●●●●
213. 23853800 c.5416G>A p.A1806T missense 0.00002471●●●●●●
214. 23862727 c.2929G>C p.V977L missense 0.00002471●●●●●●
215. 23867966 c.1862T>A p.L621H missense 0.00002471●●●●●●
216. 23855690 c.4793C>T p.S1598L missense 0.00002471●●●●●●
217. 23872977 c.746T>C p.I249T missense 0.00002200●●●●●●
218. 23859655 c.3343G>A p.A1115T missense 0.00001810●●●●●●
219. 23858227 c.4016G>A p.R1339Q missense 0.00001669●●●●●●
220. 23857131 c.4361T>A p.I1454N missense 0.00001665●●●●●●
221. 23857123 c.4369G>A p.E1457K missense 0.00001663●●●●●●
222. 23857105 c.4387G>A p.E1463K missense 0.00001660●●●●●●
223. 23857101 c.4391A>C p.E1464A missense 0.00001659●●●●●●
224. 23865593 c.2329G>A p.E777K missense 0.00001656●●●●●●
225. 23865590 c.2332A>T p.M778L missense 0.00001655●●●●●●
226. 23857541 c.4182G>C p.K1394N missense 0.00001655●●●●●●
227. 23857072 c.4420A>G p.K1474E missense 0.00001654●●●●●●
228. 23871908 c.1000G>A p.D334N missense 0.00001652●●●●●●
229. 23857063 c.4429C>T p.R1477C missense 0.00001652●●●●●●
230. 23871906 c.1002T>A p.D334E missense 0.00001652●●●●●●
231. 23858195 c.4048G>A p.E1350K missense 0.00001652●●●●●●
232. 23857062 c.4430G>A p.R1477H missense 0.00001652●●●●●●
233. 23855165 c.5135G>T p.S1712I missense 0.00001651●●●●●●
234. 23865557 c.2365C>T p.R789C missense 0.00001651●●●●●●
235. 23853674 c.5542C>T p.R1848C missense 0.00001650●●●●●●
236. 23876243 c.190G>A p.E64K missense 0.00001649●●●●●●
237. 23871807 c.1007C>A p.A336D missense 0.00001649●●●●●●
238. 23855204 c.5096G>A p.R1699Q missense 0.00001649●●●●●●
239. 23858162 c.4081C>T p.R1361C missense 0.00001649●●●●●●
240. 23855315 c.4985C>T p.A1662V missense 0.00001649●●●●●●
241. 23876426 c.7G>A p.D3N missense 0.00001649●●●●●●
242. 23869920 c.1408G>A p.D470N missense 0.00001649●●●●●●
243. 23857037 c.4455G>C p.K1485N missense 0.00001649●●●●●●
244. 23866768 c.1946T>C p.V649A missense 0.00001649●●●●●●
245. 23870162 c.1166T>C p.M389T missense 0.00001649●●●●●●
246. 23869920 c.1408G>T p.D470Y missense 0.00001649●●●●●●
247. 23866783 c.1931C>T p.S644L missense 0.00001649●●●●●●
248. 23869929 c.1399G>A p.E467K missense 0.00001648●●●●●●
249. 23858928 c.3733G>A p.A1245T missense 0.00001648●●●●●●
250. 23857398 c.4325C>T p.A1442V missense 0.00001648●●●●●●
251. 23866221 c.2119T>C p.C707R missense 0.00001648●●●●●●
252. 23866197 c.2143A>G p.I715V missense 0.00001648●●●●●●
253. 23855568 c.4915G>A p.A1639T missense 0.00001648●●●●●●
254. 23852451 c.5644C>T p.R1882C missense 0.00001648●●●●●●
255. 23852435 c.5660C>T p.A1887V missense 0.00001648●●●●●●
256. 23857405 c.4318G>T p.A1440S missense 0.00001648●●●●●●
257. 23876348 c.85C>T p.R29W missense 0.00001648●●●●●●
258. 23858906 c.3755G>A p.R1252Q missense 0.00001648●●●●●●
259. 23869955 c.1373T>C p.I458T missense 0.00001648●●●●●●
260. 23855274 c.5026G>A p.V1676M missense 0.00001648●●●●●●
261. 23858092 c.4151G>A p.R1384Q missense 0.00001648●●●●●●
262. 23866254 c.2086C>T p.R696C missense 0.00001648●●●●●●
263. 23857377 c.4346G>A p.R1449K missense 0.00001648●●●●●●
264. 23853741 c.5475G>C p.E1825D missense 0.00001648●●●●●●
265. 23852442 c.5653G>A p.E1885K missense 0.00001648●●●●●●
266. 23856981 c.4511A>G p.N1504S missense 0.00001648●●●●●●
267. 23858103 c.4140C>A p.D1380E missense 0.00001648●●●●●●
268. 23853898 c.5318A>T p.K1773M missense 0.00001648●●●●●●
269. 23874852 c.329C>T p.A110V missense 0.00001648●●●●●●
270. 23855277 c.5023A>G p.I1675V missense 0.00001648●●●●●●
271. 23871742 c.1072A>G p.M358V missense 0.00001648●●●●●●
272. 23876258 c.175G>C p.V59L missense 0.00001648●●●●●●
273. 23876365 c.68G>A p.R23H missense 0.00001648●●●●●●
274. 23870151 c.1177T>G p.S393A missense 0.00001648●●●●●●
275. 23866185 c.2155G>A p.D719N missense 0.00001648●●●●●●
276. 23856794 c.4594C>G p.R1532G missense 0.00001648●●●●●●
277. 23855264 c.5036G>A p.R1679H missense 0.00001648●●●●●●
278. 23858107 c.4136C>A p.T1379K missense 0.00001648●●●●●●
279. 23857437 c.4286A>T p.D1429V missense 0.00001647●●●●●●
280. 23858657 c.3923T>G p.L1308R missense 0.00001647●●●●●●
281. 23866021 c.2174G>T p.R725L missense 0.00001647●●●●●●
282. 23861824 c.3289G>A p.E1097K missense 0.00001647●●●●●●
283. 23851264 c.5805G>T p.M1935I missense 0.00001647●●●●●●
284. 23876314 c.119C>G p.P40R missense 0.00001647●●●●●●
285. 23862961 c.2842G>A p.E948K missense 0.00001647●●●●●●
286. 23874969 c.212T>C p.V71A missense 0.00001647●●●●●●
287. 23867974 c.1854G>A p.M618I missense 0.00001647●●●●●●
288. 23863065 c.2738A>G p.N913S missense 0.00001647●●●●●●
289. 23857456 c.4267C>A p.L1423I missense 0.00001647●●●●●●
290. 23870003 c.1325C>T p.T442M missense 0.00001647●●●●●●
291. 23851653 c.5780G>A p.R1927H missense 0.00001647●●●●●●
292. 23869511 c.1535T>C p.I512T missense 0.00001647●●●●●●
293. 23863086 c.2717G>T p.R906L missense 0.00001647●●●●●●
294. 23873549 c.691T>C p.F231L missense 0.00001647●●●●●●
295. 23855629 c.4854G>C p.K1618N missense 0.00001647●●●●●●
296. 23862727 c.2929G>A p.V977M missense 0.00001647●●●●●●
297. 23865922 c.2273A>G p.Y758C missense 0.00001647●●●●●●
298. 23870079 c.1249A>G p.S417G missense 0.00001647●●●●●●
299. 23874906 c.275T>C p.M92T missense 0.00001647●●●●●●
300. 23863371 c.2591C>T p.T864M missense 0.00001647●●●●●●
301. 23862705 c.2951T>C p.M984T missense 0.00001647●●●●●●
302. 23862181 c.3191C>T p.T1064I missense 0.00001647●●●●●●
303. 23851698 c.5735C>T p.A1912V missense 0.00001647●●●●●●
304. 23874948 c.233A>G p.Q78R missense 0.00001647●●●●●●
305. 23862631 c.3025C>G p.L1009V missense 0.00001647●●●●●●
306. 23874513 c.421G>A p.A141T missense 0.00001647●●●●●●
307. 23874507 c.427C>G p.R143G missense 0.00001647●●●●●●
308. 23866421 c.2008C>T p.H670Y missense 0.00001647●●●●●●
309. 23853866 c.5350A>G p.M1784V missense 0.00001647●●●●●●
310. 23873506 c.734T>C p.F245S missense 0.00001647●●●●●●
311. 23863087 c.2716C>A p.R906S missense 0.00001647●●●●●●
312. 23868189 c.1639A>G p.M547V missense 0.00001647●●●●●●
313. 23861839 c.3274C>G p.Q1092E missense 0.00001647●●●●●●
314. 23874449 c.485A>G p.Y162C missense 0.00001647●●●●●●
315. 23873564 c.676C>T p.P226S missense 0.00001647●●●●●●
316. 23862635 c.3021G>T p.Q1007H missense 0.00001647●●●●●●
317. 23858825 c.3836G>A p.R1279Q missense 0.00001647●●●●●●
318. 23874515 c.419C>A p.A140D missense 0.00001647●●●●●●
319. 23863408 c.2554G>A p.A852T missense 0.00001647●●●●●●
320. 23863032 c.2771T>C p.M924T missense 0.00001647●●●●●●
321. 23855702 c.4781G>A p.R1594Q missense 0.00001647●●●●●●
322. 23873994 c.568C>T p.R190C missense 0.00001647●●●●●●
323. 23873527 c.713G>A p.R238Q missense 0.00001647●●●●●●
324. 23859466 c.3532C>T p.R1178W missense 0.00001324●●●●●●
325. 23872978 c.745A>G p.I249V missense 0.00001103●●●●●●
326. 23872933 c.790A>T p.I264L missense 0.00001041●●●●●●
327. 23872938 c.785C>T p.A262V missense 0.00001038●●●●●●
328. 23859610 c.3388G>T p.A1130S missense 0.00000945●●●●●●
329. 23858254 c.3989C>T p.A1330V missense 0.00000873●●●●●●
330. 23858246 c.3997C>A p.H1333N missense 0.00000848●●●●●●
331. 23858245 c.3998A>G p.H1333R missense 0.00000845●●●●●●
332. 23855818 c.4665C>A p.H1555Q missense 0.00000840●●●●●●
333. 23855814 c.4669G>A p.E1557K missense 0.00000838●●●●●●
334. 23858233 c.4010C>T p.S1337L missense 0.00000838●●●●●●
335. 23855811 c.4672G>A p.G1558S missense 0.00000837●●●●●●
336. 23871997 c.911T>C p.V304A missense 0.00000835●●●●●●
337. 23855807 c.4676A>G p.K1559R missense 0.00000834●●●●●●
338. 23855802 c.4681C>T p.L1561F missense 0.00000833●●●●●●
339. 23858222 c.4021G>T p.D1341Y missense 0.00000833●●●●●●
340. 23855798 c.4685G>T p.R1562L missense 0.00000832●●●●●●
341. 23855798 c.4685G>A p.R1562Q missense 0.00000832●●●●●●
342. 23855799 c.4684C>T p.R1562W missense 0.00000832●●●●●●
343. 23855796 c.4687G>A p.A1563T missense 0.00000831●●●●●●
344. 23871980 c.928G>A p.D310N missense 0.00000830●●●●●●
345. 23855785 c.4698G>C p.E1566D missense 0.00000829●●●●●●
346. 23857096 c.4396C>G p.Q1466E missense 0.00000829●●●●●●
347. 23859357 c.3641G>A p.R1214Q missense 0.00000829●●●●●●
348. 23857098 c.4394C>T p.S1465L missense 0.00000829●●●●●●
349. 23871974 c.934G>A p.A312T missense 0.00000829●●●●●●
350. 23857095 c.4397A>G p.Q1466R missense 0.00000829●●●●●●
351. 23869635 c.1411T>C p.F471L missense 0.00000828●●●●●●
352. 23852509 c.5586C>G p.N1862K missense 0.00000828●●●●●●
353. 23871971 c.937T>G p.F313V missense 0.00000828●●●●●●
354. 23855144 c.5156A>G p.H1719R missense 0.00000828●●●●●●
355. 23855783 c.4700T>G p.F1567C missense 0.00000828●●●●●●
356. 23858198 c.4045T>A p.Y1349N missense 0.00000827●●●●●●
357. 23858198 c.4045T>G p.Y1349D missense 0.00000827●●●●●●
358. 23870178 c.1150A>G p.K384E missense 0.00000827●●●●●●
359. 23865587 c.2335C>T p.R779W missense 0.00000827●●●●●●
360. 23857068 c.4424A>G p.E1475G missense 0.00000827●●●●●●
361. 23855153 c.5147A>G p.Q1716R missense 0.00000827●●●●●●
362. 23855160 c.5140C>T p.R1714W missense 0.00000826●●●●●●
363. 23857065 c.4427C>T p.A1476V missense 0.00000826●●●●●●
364. 23855340 c.4960G>A p.D1654N missense 0.00000826●●●●●●
365. 23871943 c.965C>G p.A322G missense 0.00000826●●●●●●
366. 23871914 c.994G>A p.A332T missense 0.00000826●●●●●●
367. 23853656 c.5560T>C p.Y1854H missense 0.00000826●●●●●●
368. 23863514 c.2448C>G p.I816M missense 0.00000826●●●●●●
369. 23865568 c.2354G>A p.R785H missense 0.00000826●●●●●●
370. 23865584 c.2338G>A p.D780N missense 0.00000826●●●●●●
371. 23865559 c.2363C>G p.T788R missense 0.00000825●●●●●●
372. 23866793 c.1921A>C p.K641Q missense 0.00000825●●●●●●
373. 23873920 c.642G>T p.K214N missense 0.00000825●●●●●●
374. 23857045 c.4447C>T p.L1483F missense 0.00000825●●●●●●
375. 23865565 c.2357T>G p.I786S missense 0.00000825●●●●●●
376. 23866806 c.1908C>A p.S636R missense 0.00000825●●●●●●
377. 23855762 c.4721T>A p.I1574N missense 0.00000825●●●●●●
378. 23874842 c.339G>T p.M113I missense 0.00000825●●●●●●
379. 23858173 c.4070C>T p.A1357V missense 0.00000825●●●●●●
380. 23855174 c.5126T>C p.I1709T missense 0.00000825●●●●●●
381. 23874838 c.343T>C p.Y115H missense 0.00000825●●●●●●
382. 23865551 c.2371C>G p.Q791E missense 0.00000825●●●●●●
383. 23857046 c.4446G>C p.E1482D missense 0.00000825●●●●●●
384. 23855319 c.4981G>A p.D1661N missense 0.00000825●●●●●●
385. 23865565 c.2357T>A p.I786N missense 0.00000825●●●●●●
386. 23874842 c.339G>A p.M113I missense 0.00000825●●●●●●
387. 23855201 c.5099C>A p.S1700Y missense 0.00000825●●●●●●
388. 23855189 c.5111C>T p.A1704V missense 0.00000825●●●●●●
389. 23857051 c.4441A>T p.T1481S missense 0.00000825●●●●●●
390. 23871932 c.976G>T p.D326Y missense 0.00000825●●●●●●
391. 23853682 c.5534G>T p.S1845I missense 0.00000825●●●●●●
392. 23869962 c.1366T>G p.Y456D missense 0.00000824●●●●●●
393. 23866753 c.1961G>A p.R654Q missense 0.00000824●●●●●●
394. 23853881 c.5335G>T p.A1779S missense 0.00000824●●●●●●
395. 23851653 c.5780G>T p.R1927L missense 0.00000824●●●●●●
396. 23854225 c.5189A>G p.K1730R missense 0.00000824●●●●●●
397. 23866402 c.2027T>A p.I676N missense 0.00000824●●●●●●
398. 23863373 c.2589G>C p.E863D missense 0.00000824●●●●●●
399. 23855720 c.4763C>A p.A1588D missense 0.00000824●●●●●●
400. 23853919 c.5297T>C p.M1766T missense 0.00000824●●●●●●
401. 23851680 c.5753A>T p.Q1918L missense 0.00000824●●●●●●
402. 23869484 c.1562G>A p.C521Y missense 0.00000824●●●●●●
403. 23873509 c.731G>A p.R244H missense 0.00000824●●●●●●
404. 23858847 c.3814C>T p.L1272F missense 0.00000824●●●●●●
405. 23855629 c.4854G>T p.K1618N missense 0.00000824●●●●●●
406. 23853841 c.5375T>C p.I1792T missense 0.00000824●●●●●●
407. 23876347 c.86G>C p.R29P missense 0.00000824●●●●●●
408. 23873585 c.655G>T p.D219Y missense 0.00000824●●●●●●
409. 23869531 c.1515G>C p.E505D missense 0.00000824●●●●●●
410. 23853823 c.5393G>A p.R1798Q missense 0.00000824●●●●●●
411. 23857027 c.4465G>A p.A1489T missense 0.00000824●●●●●●
412. 23853742 c.5474A>T p.E1825V missense 0.00000824●●●●●●
413. 23872576 c.879C>G p.N293K missense 0.00000824●●●●●●
414. 23868176 c.1652C>T p.A551V missense 0.00000824●●●●●●
415. 23855286 c.5014A>T p.N1672Y missense 0.00000824●●●●●●
416. 23868065 c.1763A>G p.D588G missense 0.00000824●●●●●●
417. 23862711 c.2945A>G p.E982G missense 0.00000824●●●●●●
418. 23858678 c.3902C>T p.S1301L missense 0.00000824●●●●●●
419. 23874889 c.292G>C p.E98Q missense 0.00000824●●●●●●
420. 23871768 c.1046G>A p.G349D missense 0.00000824●●●●●●
421. 23867996 c.1832A>T p.Q611L missense 0.00000824●●●●●●
422. 23862551 c.3105T>G p.D1035E missense 0.00000824●●●●●●
423. 23862233 c.3139C>T p.R1047C missense 0.00000824●●●●●●
424. 23856764 c.4624C>A p.L1542M missense 0.00000824●●●●●●
425. 23874510 c.424T>C p.Y142H missense 0.00000824●●●●●●
426. 23870033 c.1295T>C p.V432A missense 0.00000824●●●●●●
427. 23862169 c.3203T>C p.I1068T missense 0.00000824●●●●●●
428. 23862676 c.2980C>A p.L994M missense 0.00000824●●●●●●
429. 23855637 c.4846G>A p.V1616M missense 0.00000824●●●●●●
430. 23863392 c.2570A>G p.E857G missense 0.00000824●●●●●●
431. 23861826 c.3287T>C p.I1096T missense 0.00000824●●●●●●
432. 23854222 c.5192A>C p.K1731T missense 0.00000824●●●●●●
433. 23874521 c.413T>C p.V138A missense 0.00000824●●●●●●
434. 23855757 c.4726C>T p.R1576W missense 0.00000824●●●●●●
435. 23854158 c.5256C>G p.N1752K missense 0.00000824●●●●●●
436. 23863299 c.2663A>G p.D888G missense 0.00000824●●●●●●
437. 23858895 c.3766G>A p.D1256N missense 0.00000824●●●●●●
438. 23857417 c.4306C>A p.R1436S missense 0.00000824●●●●●●
439. 23874018 c.544G>A p.A182T missense 0.00000824●●●●●●
440. 23853872 c.5344G>C p.E1782Q missense 0.00000824●●●●●●
441. 23873972 c.590G>A p.S197N missense 0.00000824●●●●●●
442. 23869919 c.1409A>G p.D470G missense 0.00000824●●●●●●
443. 23866287 c.2053G>A p.V685M missense 0.00000824●●●●●●
444. 23863341 c.2621A>T p.E874V missense 0.00000824●●●●●●
445. 23869526 c.1520T>C p.I507T missense 0.00000824●●●●●●
446. 23873510 c.730C>T p.R244C missense 0.00000824●●●●●●
447. 23853809 c.5407G>C p.E1803Q missense 0.00000824●●●●●●
448. 23869546 c.1500G>C p.E500D missense 0.00000824●●●●●●
449. 23868212 c.1616G>A p.C539Y missense 0.00000824●●●●●●
450. 23866390 c.2039G>A p.R680Q missense 0.00000824●●●●●●
451. 23866765 c.1949C>T p.S650L missense 0.00000824●●●●●●
452. 23854157 c.5257G>C p.A1753P missense 0.00000824●●●●●●
453. 23858803 c.3858T>A p.N1286K missense 0.00000824●●●●●●
454. 23853752 c.5464C>G p.R1822G missense 0.00000824●●●●●●
455. 23868039 c.1789A>G p.K597E missense 0.00000824●●●●●●
456. 23865916 c.2279T>C p.F760S missense 0.00000824●●●●●●
457. 23868078 c.1750G>A p.A584T missense 0.00000824●●●●●●
458. 23862588 c.3068C>T p.S1023F missense 0.00000824●●●●●●
459. 23856974 c.4518C>A p.N1506K missense 0.00000824●●●●●●
460. 23856799 c.4589A>T p.K1530M missense 0.00000824●●●●●●
461. 23853701 c.5515G>T p.V1839L missense 0.00000824●●●●●●
462. 23874937 c.244C>T p.P82S missense 0.00000824●●●●●●
463. 23862217 c.3155G>A p.R1052Q missense 0.00000824●●●●●●
464. 23874853 c.328G>A p.A110T missense 0.00000824●●●●●●
465. 23858140 c.4103C>T p.S1368L missense 0.00000824●●●●●●
466. 23857429 c.4294G>A p.V1432M missense 0.00000824●●●●●●
467. 23874576 c.358C>G p.L120V missense 0.00000824●●●●●●
468. 23871689 c.1125G>T p.E375D missense 0.00000824●●●●●●
469. 23865524 c.2398C>A p.R800S missense 0.00000824●●●●●●
470. 23855715 c.4768C>A p.R1590S missense 0.00000824●●●●●●
471. 23851690 c.5743G>A p.A1915T missense 0.00000824●●●●●●
472. 23874488 c.446A>T p.E149V missense 0.00000824●●●●●●
473. 23866754 c.1960C>T p.R654W missense 0.00000824●●●●●●
474. 23866417 c.2012T>G p.F671C missense 0.00000824●●●●●●
475. 23863377 c.2585A>G p.K862R missense 0.00000824●●●●●●
476. 23869539 c.1507A>G p.K503E missense 0.00000824●●●●●●
477. 23866275 c.2065C>A p.P689T missense 0.00000824●●●●●●
478. 23853824 c.5392C>T p.R1798W missense 0.00000824●●●●●●
479. 23869499 c.1547T>C p.M516T missense 0.00000824●●●●●●
480. 23858859 c.3802G>A p.A1268T missense 0.00000824●●●●●●
481. 23858852 c.3809G>A p.R1270H missense 0.00000824●●●●●●
482. 23857371 c.4352T>C p.F1451S missense 0.00000824●●●●●●
483. 23853865 c.5351T>A p.M1784K missense 0.00000824●●●●●●
484. 23868032 c.1796A>T p.K599M missense 0.00000824●●●●●●
485. 23853762 c.5454A>T p.E1818D missense 0.00000824●●●●●●
486. 23876258 c.175G>A p.V59I missense 0.00000824●●●●●●
487. 23872617 c.838G>T p.A280S missense 0.00000824●●●●●●
488. 23868178 c.1650G>C p.K550N missense 0.00000824●●●●●●
489. 23853735 c.5481G>C p.E1827D missense 0.00000824●●●●●●
490. 23863409 c.2553G>A p.M851I missense 0.00000824●●●●●●
491. 23868090 c.1738C>A p.L580M missense 0.00000824●●●●●●
492. 23862235 c.3137T>C p.V1046A missense 0.00000824●●●●●●
493. 23856767 c.4621G>C p.E1541Q missense 0.00000824●●●●●●
494. 23853692 c.5524A>G p.M1842V missense 0.00000824●●●●●●
495. 23868012 c.1816G>A p.V606I missense 0.00000824●●●●●●
496. 23867997 c.1831C>A p.Q611K missense 0.00000824●●●●●●
497. 23862565 c.3091C>A p.Q1031K missense 0.00000824●●●●●●
498. 23854211 c.5203G>A p.D1735N missense 0.00000824●●●●●●
499. 23856803 c.4585G>A p.E1529K missense 0.00000824●●●●●●
500. 23870122 c.1206C>A p.H402Q missense 0.00000824●●●●●●
501. 23863434 c.2528A>G p.K843R missense 0.00000824●●●●●●
502. 23862137 c.3235G>C p.E1079Q missense 0.00000824●●●●●●
503. 23861826 c.3287T>A p.I1096N missense 0.00000824●●●●●●
504. 23858103 c.4140C>G p.D1380E missense 0.00000824●●●●●●
505. 23854231 c.5183A>G p.Q1728R missense 0.00000824●●●●●●
506. 23874494 c.440G>A p.R147K missense 0.00000824●●●●●●
507. 23863304 c.2658G>C p.K886N missense 0.00000824●●●●●●
508. 23855691 c.4792T>C p.S1598P missense 0.00000824●●●●●●
509. 23853895 c.5321A>G p.E1774G missense 0.00000824●●●●●●
510. 23874432 c.502G>A p.D168N missense 0.00000824●●●●●●
511. 23855660 c.4823G>A p.R1608H missense 0.00000824●●●●●●
512. 23853875 c.5341C>A p.L1781M missense 0.00000824●●●●●●
513. 23851644 c.5789G>A p.G1930D missense 0.00000824●●●●●●
514. 23873979 c.583T>C p.F195L missense 0.00000824●●●●●●
515. 23866379 c.2050G>C p.G684R missense 0.00000824●●●●●●
516. 23858804 c.3857A>T p.N1286I missense 0.00000824●●●●●●
517. 23855576 c.4907G>A p.R1636H missense 0.00000824●●●●●●
518. 23876339 c.94G>C p.D32H missense 0.00000824●●●●●●
519. 23873546 c.694G>A p.G232S missense 0.00000824●●●●●●
520. 23855534 c.4949G>A p.S1650N missense 0.00000824●●●●●●
521. 23853812 c.5404G>A p.A1802T missense 0.00000824●●●●●●
522. 23869468 c.1578G>C p.E526D missense 0.00000824●●●●●●
523. 23866223 c.2117T>A p.I706N missense 0.00000824●●●●●●
524. 23862997 c.2806G>A p.A936T missense 0.00000824●●●●●●
525. 23868087 c.1741A>G p.I581V missense 0.00000824●●●●●●
526. 23871753 c.1061C>T p.T354M missense 0.00000824●●●●●●
527. 23856832 c.4556G>A p.G1519E missense 0.00000824●●●●●●
528. 23868044 c.1784T>A p.L595Q missense 0.00000824●●●●●●
529. 23865927 c.2268C>A p.N756K missense 0.00000824●●●●●●
530. 23862672 c.2984C>G p.T995S missense 0.00000824●●●●●●
531. 23862245 c.3127G>C p.E1043Q missense 0.00000824●●●●●●
532. 23856974 c.4518C>G p.N1506K missense 0.00000824●●●●●●
533. 23874970 c.211G>A p.V71M missense 0.00000824●●●●●●
534. 23872568 c.887C>T p.P296L missense 0.00000824●●●●●●
535. 23865521 c.2401A>T p.I801F missense 0.00000824●●●●●●
536. 23862221 c.3151G>A p.E1051K missense 0.00000824●●●●●●
537. 23862957 c.2846G>A p.C949Y missense 0.00000824●●●●●●
538. 23867987 c.1841C>T p.S614F missense 0.00000824●●●●●●
539. 23858086 c.4157A>T p.E1386V missense 0.00000824●●●●●●
540. 23857468 c.4255A>C p.T1419P missense 0.00000824●●●●●●
541. 23855740 c.4743G>T p.K1581N missense 0.00000824●●●●●●
542. 23854147 c.5267A>G p.K1756R missense 0.00000824●●●●●●
543. 23870007 c.1321G>A p.V441M missense 0.00000824●●●●●●
544. 23866762 c.1952C>T p.A651V missense 0.00000824●●●●●●
545. 23863395 c.2567A>G p.E856G missense 0.00000824●●●●●●
546. 23851665 c.5768G>A p.R1923Q missense 0.00000824●●●●●●
547. 23863386 c.2576G>C p.G859A missense 0.00000824●●●●●●
548. 23855647 c.4836G>C p.E1612D missense 0.00000824●●●●●●
549. 23873937 c.625A>G p.N209D missense 0.00000824●●●●●●
550. 23876360 c.73G>A p.E25K missense 0.00000824●●●●●●
551. 23876312 c.121G>A p.D41N missense 0.00000824●●●●●●
552. 23858874 c.3787G>T p.V1263L missense 0.00000824●●●●●●
553. 23857410 c.4313A>T p.N1438I missense 0.00000824●●●●●●
554. 23874919 c.262G>C p.E88Q missense 0.00000824●●●●●●
555. 23855633 c.4850A>C p.K1617T missense 0.00000824●●●●●●
556. 23876398 c.35C>T p.A12V missense 0.00000824●●●●●●
557. 23865982 c.2213T>C p.I738T missense 0.00000824●●●●●●
558. 23870143 c.1185C>G p.D395E missense 0.00000824●●●●●●
559. 23868101 c.1727C>T p.A576V missense 0.00000824●●●●●●
560. 23866178 c.2162G>A p.R721Q missense 0.00000824●●●●●●
561. 23862909 c.2894A>C p.K965T missense 0.00000824●●●●●●
562. 23858720 c.3860G>A p.G1287E missense 0.00000824●●●●●●
563. 23876314 c.119C>T p.P40L missense 0.00000824●●●●●●
564. 23858667 c.3913C>T p.R1305W missense 0.00000824●●●●●●
565. 23853788 c.5428G>A p.G1810S missense 0.00000824●●●●●●
566. 23872640 c.815C>T p.S272F missense 0.00000824●●●●●●
567. 23866199 c.2141G>A p.R714H missense 0.00000824●●●●●●
568. 23855229 c.5071C>T p.R1691C missense 0.00000824●●●●●●
569. 23853694 c.5522G>A p.G1841D missense 0.00000824●●●●●●
570. 23874913 c.268A>G p.M90V missense 0.00000824●●●●●●
571. 23868023 c.1805T>C p.L602P missense 0.00000824●●●●●●
572. 23868003 c.1825C>A p.L609M missense 0.00000824●●●●●●
573. 23867962 c.1866C>A p.F622L missense 0.00000824●●●●●●
574. 23854222 c.5192A>T p.K1731M missense 0.00000824●●●●●●
575. 23851768 c.5665G>A p.E1889K missense 0.00000824●●●●●●
576. 23855612 c.4871T>C p.L1624P missense 0.00000824●●●●●●
577. 23867937 c.1891G>A p.G631R missense 0.00000824●●●●●●
578. 23863459 c.2503T>C p.Y835H missense 0.00000824●●●●●●
579. 23858150 c.4093A>G p.K1365E missense 0.00000824●●●●●●
580. 23856773 c.4615A>C p.K1539Q missense 0.00000824●●●●●●
581. 23862152 c.3220G>T p.D1074Y missense 0.00000824●●●●●●
582. 23851645 c.5788G>C p.G1930R missense 0.00000824●●●●●●
583. 23866396 c.2033A>G p.N678S missense 0.00000824●●●●●●
584. 23863357 c.2605G>A p.E869K missense 0.00000824●●●●●●
585. 23857431 c.4292T>C p.M1431T missense 0.00000824●●●●●●
586. 23858912 c.3749T>A p.V1250E missense 0.00000824●●●●●●
587. 23857428 c.4295T>A p.V1432E missense 0.00000824●●●●●●
588. 23855715 c.4768C>T p.R1590C missense 0.00000824●●●●●●
589. 23869956 c.1372A>G p.I458V missense 0.00000824●●●●●●
590. 23855261 c.5039A>T p.N1680I missense 0.00000824●●●●●●
591. 23858823 c.3838G>A p.A1280T missense 0.00000824●●●●●●
592. 23853827 c.5389C>G p.H1797D missense 0.00000824●●●●●●
593. 23876344 c.89C>G p.P30R missense 0.00000824●●●●●●
594. 23869524 c.1522G>C p.E508Q missense 0.00000824●●●●●●
595. 23855565 c.4918G>A p.E1640K missense 0.00000824●●●●●●
596. 23853815 c.5401G>A p.E1801K missense 0.00000824●●●●●●
597. 23870021 c.1307T>C p.M436T missense 0.00000824●●●●●●
598. 23869481 c.1565T>C p.I522T missense 0.00000824●●●●●●
599. 23866224 c.2116A>T p.I706F missense 0.00000824●●●●●●
600. 23863075 c.2728C>A p.L910M missense 0.00000824●●●●●●
601. 23858858 c.3803C>G p.A1268G missense 0.00000824●●●●●●
602. 23857405 c.4318G>C p.A1440P missense 0.00000824●●●●●●
603. 23872573 c.882G>C p.K294N missense 0.00000824●●●●●●
604. 23868045 c.1783C>G p.L595V missense 0.00000824●●●●●●
605. 23865973 c.2222G>A p.R741K missense 0.00000824●●●●●●
606. 23862682 c.2974G>A p.A992T missense 0.00000824●●●●●●
607. 23870052 c.1276G>A p.G426R missense 0.00000824●●●●●●
608. 23856988 c.4504C>T p.R1502W missense 0.00000824●●●●●●
609. 23855309 c.4991G>A p.R1664H missense 0.00000824●●●●●●
610. 23867988 c.1840T>G p.S614A missense 0.00000824●●●●●●
611. 23862248 c.3124C>A p.Q1042K missense 0.00000824●●●●●●
612. 23862232 c.3140G>A p.R1047H missense 0.00000824●●●●●●
613. 23856761 c.4627C>A p.Q1543K missense 0.00000824●●●●●●
614. 23871800 c.1014C>A p.D338E missense 0.00000824●●●●●●
615. 23852489 c.5606T>C p.L1869P missense 0.00000824●●●●●●
616. 23858093 c.4150C>T p.R1384W missense 0.00000824●●●●●●
617. 23854154 c.5260G>C p.E1754Q missense 0.00000824●●●●●●
618. 23851726 c.5707C>A p.H1903N missense 0.00000824●●●●●●
619. 23874507 c.427C>T p.R143W missense 0.00000824●●●●●●
620. 23870027 c.1301A>C p.E434A missense 0.00000824●●●●●●
621. 23857378 c.4345A>G p.R1449G missense 0.00000824●●●●●●
622. 23873952 c.610C>T p.R204C missense 0.00000824●●●●●●
623. 23869560 c.1486G>C p.V496L missense 0.00000824●●●●●●
624. 23866277 c.2063A>G p.N688S missense 0.00000824●●●●●●
625. 23863333 c.2629G>A p.E877K missense 0.00000824●●●●●●
626. 23873522 c.718G>A p.D240N missense 0.00000824●●●●●●
627. 23876340 c.93T>G p.F31L missense 0.00000824●●●●●●
628. 23866271 c.2069T>A p.L690Q missense 0.00000824●●●●●●
629. 23863105 c.2698C>A p.L900I missense 0.00000824●●●●●●
630. 23858890 c.3771G>T p.Q1257H missense 0.00000824●●●●●●
631. 23855661 c.4822C>G p.R1608G missense 0.00000824●●●●●●
632. 23876383 c.50G>A p.R17H missense 0.00000824●●●●●●
633. 23876305 c.128A>G p.K43R missense 0.00000824●●●●●●
634. 23868190 c.1638C>A p.D546E missense 0.00000824●●●●●●
635. 23866200 c.2140C>T p.R714C missense 0.00000824●●●●●●
636. 23866004 c.2191G>T p.A731S missense 0.00000824●●●●●●
637. 23866019 c.2176A>T p.I726F missense 0.00000824●●●●●●
638. 23862940 c.2863G>C p.D955H missense 0.00000824●●●●●●
639. 23858803 c.3858T>G p.N1286K missense 0.00000824●●●●●●
640. 23876332 c.101G>A p.R34H missense 0.00000824●●●●●●
641. 23865525 c.2397G>A p.M799I missense 0.00000824●●●●●●
642. 23868011 c.1817T>C p.V606A missense 0.00000824●●●●●●
643. 23862579 c.3077A>C p.K1026T missense 0.00000824●●●●●●
644. 23856853 c.4535C>T p.S1512L missense 0.00000824●●●●●●
645. 23874957 c.224A>G p.Q75R missense 0.00000824●●●●●●
646. 23853695 c.5521G>A p.G1841S missense 0.00000824●●●●●●
647. 23862928 c.2875C>G p.L959V missense 0.00000824●●●●●●
648. 23874928 c.253G>A p.D85N missense 0.00000824●●●●●●
649. 23868029 c.1799A>T p.D600V missense 0.00000824●●●●●●
650. 23865904 c.2291A>C p.K764T missense 0.00000824●●●●●●
651. 23862176 c.3196G>A p.E1066K missense 0.00000824●●●●●●
652. 23852450 c.5645G>T p.R1882L missense 0.00000824●●●●●●
653. 23874551 c.383A>G p.Y128C missense 0.00000824●●●●●●
654. 23871685 c.1129G>C p.D377H missense 0.00000824●●●●●●
655. 23851770 c.5663A>C p.E1888A missense 0.00000824●●●●●●
656. 23867952 c.1876G>A p.A626T missense 0.00000824●●●●●●
657. 23863474 c.2488C>T p.P830S missense 0.00000824●●●●●●
658. 23862209 c.3163C>T p.R1055W missense 0.00000824●●●●●●
659. 23856786 c.4602G>C p.Q1534H missense 0.00000824●●●●●●

* This highlights the relative frequency of the variant in the ExAC populations - Non-Finnish European, African, East Asian, South Asian, American and Finnish. Higher frequencies are denoted by darker shades of green, variants absent in a population are coloured light gray.

✝ Genomic coordinates refer to the GRCh37 release of the human genome.