TRDN missense variants in ExAC

TRDN gene summary
TRDN variants in

The table below lists the TRDN missense variants found in the ExAC population database. Click on each variant for more details, including presence in the 1000 Genomes and Exome Sequencing Project databases, a breakdown by ethnic class and the variant's role in inherited cardiac disease. Use the form below to customise the variant selection. The table can be sorted by variant location, variant type or ExAC frequency.




No. Genomic coord.✝ Variant (CDS)▼ Variant (Protein) Variant Type▼ ExAC frequency▼Populations*
1. 123687288 c.1313T>G p.I438S missense 0.92397194●●●●●●
2. 123833457 c.601C>G p.L201V missense 0.82588013●●●●●●
3. 123869607 c.383C>G p.T128S missense 0.49255762●●●●●●
4. 123699019 c.1211T>G p.V404G missense 0.20036793●●●●●●
5. 123696766 c.1257C>A p.D419E missense 0.13740491●●●●●●
6. 123658776 c.1408C>A p.L470M missense 0.05786695●●●●●●
7. 123594486 c.1620A>G p.I540M missense 0.03434877●●●●●●
8. 123868506 c.403G>A p.E135K missense 0.00730602●●●●●●
9. 123687288 c.1313T>A p.I438N missense 0.00691466●●●●●●
10. 123759243 c.1016G>A p.S339N missense 0.00519268●●●●●●
11. 123714778 c.1096G>A p.A366T missense 0.00511020●●●●●●
12. 123851705 c.430C>T p.H144Y missense 0.00403226●●●●●●
13. 123869716 c.274G>A p.V92I missense 0.00353237●●●●●●
14. 123837334 c.502G>A p.E168K missense 0.00190785●●●●●●
15. 123673686 c.1367A>G p.Q456R missense 0.00122751●●●●●●
16. 123592291 c.1713A>C p.E571D missense 0.00074613●●●●●●
17. 123869623 c.367G>A p.D123N missense 0.00069724●●●●●●
18. 123637602 c.1510G>A p.G504S missense 0.00060415●●●●●●
19. 123600207 c.1531C>A p.P511T missense 0.00056502●●●●●●
20. 123824929 c.728C>T p.T243I missense 0.00052796●●●●●●
21. 123869713 c.277C>T p.R93C missense 0.00048683●●●●●●
22. 123581777 c.1811C>A p.T604K missense 0.00041182●●●●●●
23. 123869751 c.239C>T p.S80F missense 0.00036441●●●●●●
24. 123594154 c.1627C>A p.Q543K missense 0.00034638●●●●●●
25. 123892229 c.71T>A p.V24E missense 0.00033970●●●●●●
26. 123818394 c.797A>G p.Q266R missense 0.00030098●●●●●●
27. 123580775 c.1864A>G p.S622G missense 0.00029234●●●●●●
28. 123592313 c.1691A>G p.Q564R missense 0.00027076●●●●●●
29. 123868490 c.419A>G p.K140R missense 0.00023215●●●●●●
30. 123577023 c.1895G>A p.R632K missense 0.00022802●●●●●●
31. 123714819 c.1055C>T p.P352L missense 0.00021977●●●●●●
32. 123595807 c.1576A>C p.I526L missense 0.00021461●●●●●●
33. 123786098 c.884C>T p.P295L missense 0.00017182●●●●●●
34. 123699037 c.1193A>T p.E398V missense 0.00015559●●●●●●
35. 123824963 c.694C>A p.Q232K missense 0.00014978●●●●●●
36. 123833483 c.575A>C p.K192T missense 0.00012711●●●●●●
37. 123594112 c.1669C>T p.P557S missense 0.00012361●●●●●●
38. 123786069 c.913G>A p.A305T missense 0.00011946●●●●●●
39. 123588881 c.1754G>A p.R585Q missense 0.00010692●●●●●●
40. 123714811 c.1063G>T p.A355S missense 0.00009972●●●●●●
41. 123892215 c.85G>A p.G29R missense 0.00009113●●●●●●
42. 123687319 c.1282C>G p.R428G missense 0.00008458●●●●●●
43. 123702527 c.1174C>T p.P392S missense 0.00007568●●●●●●
44. 123760089 c.991G>A p.E331K missense 0.00007484●●●●●●
45. 123539749 c.2187G>T p.Q729H missense 0.00006788●●●●●●
46. 123892275 c.25A>G p.N9D missense 0.00006681●●●●●●
47. 123869625 c.365A>G p.D122G missense 0.00006578●●●●●●
48. 123539805 c.2131C>T p.R711C missense 0.00006362●●●●●●
49. 123714769 c.1105G>A p.A369T missense 0.00006343●●●●●●
50. 123892172 c.128C>T p.T43M missense 0.00005798●●●●●●
51. 123577024 c.1894A>G p.R632G missense 0.00005703●●●●●●
52. 123539852 c.2084A>T p.D695V missense 0.00005290●●●●●●
53. 123687297 c.1304C>T p.A435V missense 0.00005038●●●●●●
54. 123892104 c.196G>A p.V66I missense 0.00004971●●●●●●
55. 123837286 c.550G>T p.A184S missense 0.00004939●●●●●●
56. 123580793 c.1846G>A p.E616K missense 0.00004881●●●●●●
57. 123599486 c.1544A>G p.Q515R missense 0.00004836●●●●●●
58. 123599483 c.1547G>A p.G516E missense 0.00004828●●●●●●
59. 123599483 c.1547G>C p.G516A missense 0.00004828●●●●●●
60. 123703263 c.1165G>T p.V389L missense 0.00004818●●●●●●
61. 123837351 c.485T>G p.V162G missense 0.00004804●●●●●●
62. 123837345 c.491A>G p.H164R missense 0.00004766●●●●●●
63. 123586466 c.1801C>G p.P601A missense 0.00004680●●●●●●
64. 123576267 c.1910C>T p.S637L missense 0.00004648●●●●●●
65. 123576265 c.1912A>G p.T638A missense 0.00004643●●●●●●
66. 123576246 c.1931A>C p.Q644P missense 0.00004597●●●●●●
67. 123581777 c.1811C>T p.T604I missense 0.00004576●●●●●●
68. 123581780 c.1808G>C p.G603A missense 0.00004564●●●●●●
69. 123592304 c.1700C>A p.A567D missense 0.00004557●●●●●●
70. 123592304 c.1700C>T p.A567V missense 0.00004557●●●●●●
71. 123588864 c.1771T>C p.S591P missense 0.00004479●●●●●●
72. 123595800 c.1583A>G p.K528R missense 0.00004467●●●●●●
73. 123581769 c.1819G>A p.V607I missense 0.00004464●●●●●●
74. 123696774 c.1249C>G p.P417A missense 0.00004393●●●●●●
75. 123588870 c.1765C>A p.P589T missense 0.00004341●●●●●●
76. 123594153 c.1628A>G p.Q543R missense 0.00004311●●●●●●
77. 123759217 c.1042G>C p.E348Q missense 0.00004143●●●●●●
78. 123786122 c.860G>A p.S287N missense 0.00004027●●●●●●
79. 123833467 c.591A>C p.E197D missense 0.00003985●●●●●●
80. 123760093 c.987G>T p.K329N missense 0.00003728●●●●●●
81. 123869655 c.335A>T p.D112V missense 0.00003631●●●●●●
82. 123824930 c.727A>G p.T243A missense 0.00003560●●●●●●
83. 123590999 c.1733C>A p.P578Q missense 0.00003533●●●●●●
84. 123687297 c.1304C>A p.A435E missense 0.00003359●●●●●●
85. 123957904 c.17C>T p.A6V missense 0.00003331●●●●●●
86. 123892175 c.125C>T p.T42M missense 0.00003313●●●●●●
87. 123892166 c.134G>T p.S45I missense 0.00003313●●●●●●
88. 123818379 c.812G>C p.R271P missense 0.00003258●●●●●●
89. 123539804 c.2132G>A p.R711H missense 0.00003147●●●●●●
90. 123539843 c.2093A>G p.N698S missense 0.00003124●●●●●●
91. 123539801 c.2135C>T p.P712L missense 0.00003056●●●●●●
92. 123539793 c.2143A>G p.S715G missense 0.00002863●●●●●●
93. 123759232 c.1027A>T p.T343S missense 0.00002786●●●●●●
94. 123539826 c.2110T>A p.F704I missense 0.00002596●●●●●●
95. 123687318 c.1283G>A p.R428Q missense 0.00002537●●●●●●
96. 123824903 c.754G>T p.D252Y missense 0.00002522●●●●●●
97. 123542661 c.2021C>A p.T674N missense 0.00002521●●●●●●
98. 123673692 c.1361T>C p.V454A missense 0.00002520●●●●●●
99. 123545256 c.1996G>A p.A666T missense 0.00002503●●●●●●
100. 123539822 c.2114C>T p.P705L missense 0.00002499●●●●●●
101. 123892248 c.52G>C p.D18H missense 0.00002487●●●●●●
102. 123892173 c.127A>G p.T43A missense 0.00002485●●●●●●
103. 123588852 c.1783G>A p.D595N missense 0.00002432●●●●●●
104. 123833453 c.605C>T p.A202V missense 0.00002405●●●●●●
105. 123824962 c.695A>C p.Q232P missense 0.00002288●●●●●●
106. 123588863 c.1772C>G p.S591C missense 0.00002259●●●●●●
107. 123709696 c.1106C>T p.A369V missense 0.00002233●●●●●●
108. 123709672 c.1130A>G p.K377R missense 0.00002163●●●●●●
109. 123588873 c.1762G>A p.E588K missense 0.00002153●●●●●●
110. 123824951 c.706A>G p.K236E missense 0.00002138●●●●●●
111. 123869706 c.284C>T p.A95V missense 0.00002077●●●●●●
112. 123786080 c.902G>A p.R301K missense 0.00002027●●●●●●
113. 123539798 c.2138G>A p.G713E missense 0.00001990●●●●●●
114. 123786121 c.861C>A p.S287R missense 0.00001985●●●●●●
115. 123869680 c.310T>A p.Y104N missense 0.00001965●●●●●●
116. 123786117 c.865G>A p.A289T missense 0.00001954●●●●●●
117. 123824998 c.659A>G p.K220R missense 0.00001853●●●●●●
118. 123595794 c.1589C>G p.A530G missense 0.00001794●●●●●●
119. 123539849 c.2087G>A p.G696E missense 0.00001701●●●●●●
120. 123539754 c.2182G>A p.G728R missense 0.00001701●●●●●●
121. 123600219 c.1519G>A p.V507I missense 0.00001693●●●●●●
122. 123600201 c.1537C>A p.Q513K missense 0.00001685●●●●●●
123. 123673722 c.1331G>A p.G444E missense 0.00001682●●●●●●
124. 123869638 c.352G>T p.D118Y missense 0.00001680●●●●●●
125. 123687294 c.1307T>C p.V436A missense 0.00001677●●●●●●
126. 123957907 c.14C>G p.T5S missense 0.00001666●●●●●●
127. 123892104 c.196G>T p.V66F missense 0.00001657●●●●●●
128. 123892181 c.119T>C p.I40T missense 0.00001657●●●●●●
129. 123892211 c.89A>G p.K30R missense 0.00001657●●●●●●
130. 123892127 c.173T>A p.I58N missense 0.00001657●●●●●●
131. 123869633 c.357A>C p.E119D missense 0.00001649●●●●●●
132. 123824992 c.665T>G p.V222G missense 0.00001621●●●●●●
133. 123759256 c.1003A>C p.I335L missense 0.00001576●●●●●●
134. 123539844 c.2092A>C p.N698H missense 0.00001576●●●●●●
135. 123714819 c.1055C>A p.P352Q missense 0.00001465●●●●●●
136. 123759240 c.1019A>G p.E340G missense 0.00001445●●●●●●
137. 123714814 c.1060A>G p.K354E missense 0.00001441●●●●●●
138. 123759216 c.1043A>G p.E348G missense 0.00001382●●●●●●
139. 123539827 c.2109G>T p.Q703H missense 0.00001301●●●●●●
140. 123542654 c.2028T>G p.D676E missense 0.00001225●●●●●●
141. 123824966 c.691A>G p.K231E missense 0.00001176●●●●●●
142. 123539814 c.2122C>T p.P708S missense 0.00001172●●●●●●
143. 123824950 c.707A>C p.K236T missense 0.00001069●●●●●●
144. 123539801 c.2135C>G p.P712R missense 0.00001019●●●●●●
145. 123824944 c.713A>G p.K238R missense 0.00000965●●●●●●
146. 123539787 c.2149G>T p.G717C missense 0.00000917●●●●●●
147. 123595795 c.1588G>A p.A530T missense 0.00000896●●●●●●
148. 123595806 c.1577T>C p.I526T missense 0.00000893●●●●●●
149. 123595803 c.1580A>G p.K527R missense 0.00000893●●●●●●
150. 123595801 c.1582A>G p.K528E missense 0.00000893●●●●●●
151. 123590997 c.1735A>G p.T579A missense 0.00000884●●●●●●
152. 123539776 c.2160T>G p.N720K missense 0.00000873●●●●●●
153. 123687322 c.1279G>C p.E427Q missense 0.00000848●●●●●●
154. 123600220 c.1518A>T p.E506D missense 0.00000847●●●●●●
155. 123600206 c.1532C>T p.P511L missense 0.00000843●●●●●●
156. 123687303 c.1298T>C p.I433T missense 0.00000840●●●●●●
157. 123824897 c.760G>A p.E254K missense 0.00000840●●●●●●
158. 123824867 c.790A>G p.K264E missense 0.00000840●●●●●●
159. 123637606 c.1506A>C p.K502N missense 0.00000839●●●●●●
160. 123824895 c.762G>C p.E254D missense 0.00000839●●●●●●
161. 123892277 c.23G>C p.G8A missense 0.00000838●●●●●●
162. 123545250 c.2002A>C p.K668Q missense 0.00000835●●●●●●
163. 123545273 c.1979A>G p.D660G missense 0.00000835●●●●●●
164. 123545243 c.2009C>T p.A670V missense 0.00000835●●●●●●
165. 123545263 c.1989T>A p.D663E missense 0.00000834●●●●●●
166. 123545264 c.1988A>G p.D663G missense 0.00000834●●●●●●
167. 123545262 c.1990G>A p.V664I missense 0.00000834●●●●●●
168. 123957913 c.8A>T p.E3V missense 0.00000833●●●●●●
169. 123957920 c.1A>G p.Met1? missense 0.00000833●●●●●●
170. 123892268 c.32C>T p.S11F missense 0.00000832●●●●●●
171. 123892079 c.221A>G p.K74R missense 0.00000830●●●●●●
172. 123892076 c.224A>T p.N75I missense 0.00000830●●●●●●
173. 123892100 c.200T>C p.M67T missense 0.00000829●●●●●●
174. 123892220 c.80C>T p.S27F missense 0.00000829●●●●●●
175. 123698878 c.1229C>A p.P410Q missense 0.00000829●●●●●●
176. 123892249 c.51A>G p.I17M missense 0.00000829●●●●●●
177. 123892220 c.80C>G p.S27C missense 0.00000829●●●●●●
178. 123698885 c.1222A>G p.K408E missense 0.00000829●●●●●●
179. 123892218 c.82C>T p.P28S missense 0.00000829●●●●●●
180. 123892196 c.104C>T p.T35I missense 0.00000828●●●●●●
181. 123892166 c.134G>A p.S45N missense 0.00000828●●●●●●
182. 123892121 c.179G>T p.W60L missense 0.00000828●●●●●●
183. 123892124 c.176C>T p.T59M missense 0.00000828●●●●●●
184. 123892182 c.118A>G p.I40V missense 0.00000828●●●●●●
185. 123892175 c.125C>G p.T42R missense 0.00000828●●●●●●
186. 123892184 c.116A>T p.D39V missense 0.00000828●●●●●●
187. 123892215 c.85G>C p.G29R missense 0.00000828●●●●●●

* This highlights the relative frequency of the variant in the ExAC populations - Non-Finnish European, African, East Asian, South Asian, American and Finnish. Higher frequencies are denoted by darker shades of green, variants absent in a population are coloured light gray.

✝ Genomic coordinates refer to the GRCh37 release of the human genome.