Paralogue Annotation for KCNQ1 residue 417

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 417
Reference Amino Acid: V - Valine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 417

No paralogue variants have been mapped to residue 417 for KCNQ1.



KCNQ1-----------------TLLSPSPKPKKSV>V<VKKKKFKLDKDNGV----------------431
KCNQ2E-PSP-SKG--SP-CRGPLCGCCPGRSSQK>V<SLKDRV-FSSPRGV----------------450
KCNQ3-------------------KEQLEAASSQK>L<GLLDRVRLSNPRGS----------------438
KCNQ4D-GAP-SRYPPVATCHRPGSTSFCPGESSR>M<GIKDRIRMGSSQRR----------------448
KCNQ5-----------LHTCSPTKKEQGEASSSQK>L<SFKERVRMASPRGQ----------------433
KCNA1HYRQV-NIR--------------------->-<------------------------------474
KCNA10-G---------------------------->-<------------------------------502
KCNA2-FREE-NLK--------------------->-<------------------------------478
KCNA3PFKTG-N-S--------------------->-<------------------------------552
KCNA4AKEEKCQGK--------------------->-<------------------------------632
KCNA5SNVD-------------------------->-<------------------------------595
KCNA6SYLPT------------------------->-<------------------------------515
KCNA7--LPP-P----------------------->-<------------------------------443
KCNB1NHLSPNKWKW-------------------->-<--TKRTLSETSSSK----------------502
KCNB2NHLSPSRWKW-------------------->-<--ARKALSETSSNK----------------506
KCNC1AKAALANED--------------------->-<------------------------------518
KCNC2---VLSGDD--------------------->-<------------------------------544
KCNC3AAAALAHED--------------------->-<------------------------------676
KCNC4ANAVLSDEE--------------------->-<------------------------------554
KCND1HHLLHCLEKT-------------------->-<-------------T----------------489
KCND2HHLLHCLEKT-------------------->-<-------------T----------------489
KCND3HHLLHCLEKT-------------------->-<-------------TGLSYLVDDPLLSVRTS503
KCNF1LKLSHSDTF--------------------->-<--------IPLLTE----------------482
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1M----------------------------->-<------------------------------525
KCNS2SL---------------------------->-<------------------------------476
KCNS3SSIEDNEDI--------------------->-<--------CNTTSL----------------485
KCNV1DF---------------------------->-<--------W---------------------499
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.V417Mc.1249G>A Putative Benignrs267607197SIFT: tolerated
Polyphen: benign