Paralogue Annotation for KCNQ1 residue 430

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 430
Reference Amino Acid: G - Glycine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 430

No paralogue variants have been mapped to residue 430 for KCNQ1.



KCNQ1----TLLSPSPKPKKSVVVKKKKFKLDKDN>G<V-------------------TP-GEKMLTV440
KCNQ2-CRGPLCGCCPGRSSQKVSLKDRV-FSSPR>G<V-------------------AAKGKGSPQA460
KCNQ3------KEQLEAASSQKLGLLDRVRLSNPR>G<S-------------------NTKGKL----444
KCNQ4TCHRPGSTSFCPGESSRMGIKDRIRMGSSQ>R<R-------------------TGPSKQHLAP458
KCNQ5TCSPTKKEQGEASSSQKLSFKERVRMASPR>G<Q-------------------SIKSRQ--AS441
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1--------------------TKRTLSETSS>S<K-------------------SFETKEQGSP512
KCNB2--------------------ARKALSETSS>N<K-------------------SFENKYQEVS516
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1------------------------------>-<T-------------------CHE-------492
KCND2------------------------------>-<T-------------------NHE-------492
KCND3------------------------------>-<TGLSYLVDDPLLSVRTSTIKNHE-------509
KCNF1--------------------------IPLL>T<E-----------------------------482
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3--------------------------CNTT>S<L-------------------ENCTA-----490
KCNV1--------------------------W--->-<------------------------------499
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.G430Rc.1288G>A Putative Benignrs267602833SIFT: tolerated
Polyphen: probably damaging