Paralogue Annotation for KCNQ1 residue 442

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 442
Reference Amino Acid: H - Histidine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 442

No paralogue variants have been mapped to residue 442 for KCNQ1.



KCNQ1-------------------TP-GEKMLTVP>H<ITCDPPEERRL--------DHFSVDGYDSS464
KCNQ2-------------------AAKGKGSPQAQ>T<VRRSPSADQSLED-SPSKVPKSW--SFGDR489
KCNQ3-------------------NTKGKL----->-<--FTPLNVDAIEE-SPSKEPKPV--GLNNK469
KCNQ4-------------------TGPSKQHLAPP>T<MPTSPSSEQVGEATSPTKVQKSW--SFNDR488
KCNQ5-------------------SIKSRQ--ASV>G<DRRSPSTDITAEG-SPTKVQKSW--SFNDR470
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1-------------------SFETKEQGSPE>K<-------ARSSSSPQH-----L--------524
KCNB2-------------------SFENKYQEVSQ>K<DSHEQLNNTSSSSPQH-----L--------535
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1-------------------CHE-------->-<--------F------------T--------494
KCND2-------------------NHE-------->-<--------F------------V--------494
KCND3GLSYLVDDPLLSVRTSTIKNHE-------->-<--------F------------I--------511
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3-------------------ENCTA------>-<------------------------------490
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.H442Dc.1324C>G Putative Benignrs72549409SIFT: tolerated
Polyphen: benign
p.H442Rc.1325A>G Putative BenignSIFT:
Polyphen: