Paralogue Annotation for KCNQ1 residue 447

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 447
Reference Amino Acid: P - Proline
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 447

No paralogue variants have been mapped to residue 447 for KCNQ1.



KCNQ1--------------TP-GEKMLTVPHITCD>P<PEERRL--------DHFSVDGYDSSVRKSP469
KCNQ2--------------AAKGKGSPQAQTVRRS>P<SADQSLED-SPSKVPKSW--SFGDRSRARQ494
KCNQ3--------------NTKGKL--------FT>P<LNVDAIEE-SPSKEPKPV--GLNNKERFRT474
KCNQ4--------------TGPSKQHLAPPTMPTS>P<SSEQVGEATSPTKVQKSW--SFNDRTRFRA493
KCNQ5--------------SIKSRQ--ASVGDRRS>P<STDITAEG-SPTKVQKSW--SFNDRTRFRP475
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1--------------SFETKEQGSPEK---->-<--ARSSSSPQH-----L-------------524
KCNB2--------------SFENKYQEVSQKDSHE>Q<LNNTSSSSPQH-----L-------------535
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1--------------CHE------------->-<---F------------T-------------494
KCND2--------------NHE------------->-<---F------------V-------------494
KCND3VDDPLLSVRTSTIKNHE------------->-<---F------------I-------------511
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3--------------ENCTA----------->-<------------------------------490
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P447Hc.1340C>A Putative Benignrs143149582SIFT: tolerated
Polyphen: benign