Paralogue Annotation for KCNQ1 residue 449

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 449
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 449

No paralogue variants have been mapped to residue 449 for KCNQ1.



KCNQ1------------TP-GEKMLTVPHITCDPP>E<ERRL--------DHFSVDGYDSSVRKSPTL471
KCNQ2------------AAKGKGSPQAQTVRRSPS>A<DQSLED-SPSKVPKSW--SFGDRSRARQAF496
KCNQ3------------NTKGKL--------FTPL>N<VDAIEE-SPSKEPKPV--GLNNKERFRTAF476
KCNQ4------------TGPSKQHLAPPTMPTSPS>S<EQVGEATSPTKVQKSW--SFNDRTRFRASL495
KCNQ5------------SIKSRQ--ASVGDRRSPS>T<DITAEG-SPTKVQKSW--SFNDRTRFRPSL477
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1------------SFETKEQGSPEK------>-<ARSSSSPQH-----L---------------524
KCNB2------------SFENKYQEVSQKDSHEQL>N<NTSSSSPQH-----L---------------535
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1------------CHE--------------->-<-F------------T---------------494
KCND2------------NHE--------------->-<-F------------V---------------494
KCND3DPLLSVRTSTIKNHE--------------->-<-F------------I---------------511
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------ENCTA------------->-<------------------------------490
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E449Kc.1345G>A Putative Benignrs372583676SIFT: tolerated
Polyphen: benign