Paralogue Annotation for KCNQ1 residue 450

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 450
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 450

No paralogue variants have been mapped to residue 450 for KCNQ1.



KCNQ1-----------TP-GEKMLTVPHITCDPPE>E<RRL--------DHFSVDGYDSSVRKSPTLL472
KCNQ2-----------AAKGKGSPQAQTVRRSPSA>D<QSLED-SPSKVPKSW--SFGDRSRARQAF-496
KCNQ3-----------NTKGKL--------FTPLN>V<DAIEE-SPSKEPKPV--GLNNKERFRTAF-476
KCNQ4-----------TGPSKQHLAPPTMPTSPSS>E<QVGEATSPTKVQKSW--SFNDRTRFRASL-495
KCNQ5-----------SIKSRQ--ASVGDRRSPST>D<ITAEG-SPTKVQKSW--SFNDRTRFRPSL-477
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1-----------SFETKEQGSPEK------->A<RSSSSPQH-----L---------------N525
KCNB2-----------SFENKYQEVSQKDSHEQLN>N<TSSSSPQH-----L---------------S536
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1-----------CHE---------------->-<F------------T---------------D495
KCND2-----------NHE---------------->-<F------------V---------------D495
KCND3PLLSVRTSTIKNHE---------------->-<F------------I---------------D512
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3-----------ENCTA-------------->-<------------------------------490
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E450Kc.1348G>A Putative Benignrs148266527SIFT: tolerated
Polyphen: benign