Paralogue Annotation for KCNQ1 residue 473

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 473
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 473

No paralogue variants have been mapped to residue 473 for KCNQ1.



KCNQ1RRL--------DHFSVDGYDSSVRKSPTLL>E<V---SM------------------------476
KCNQ2QSLED-SPSKVPKSW--SFGDRSRARQAF->-<----RIKG----------------------500
KCNQ3DAIEE-SPSKEPKPV--GLNNKERFRTAF->-<----RMKA----------------------480
KCNQ4QVGEATSPTKVQKSW--SFNDRTRFRASL->-<----RLK-----------------------498
KCNQ5ITAEG-SPTKVQKSW--SFNDRTRFRPSL->-<----RLKS------------S---------482
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1RSSSSPQH-----L---------------N>V<QQLEDMYNKMAKTQ--SQPILNTKESAAQ-553
KCNB2TSSSSPQH-----L---------------S>A<QKLEMLYNEITKTQPHSHPNPDCQEKPERP567
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1F------------T---------------D>E<L-----------------------------497
KCND2F------------V---------------D>E<Q-----------------------------497
KCND3F------------I---------------D>E<Q-----------------------------514
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E473Qc.1417G>C Putative BenignSIFT:
Polyphen: