Paralogue Annotation for KCNQ1 residue 486

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 486
Reference Amino Acid: A - Alanine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 486

No paralogue variants have been mapped to residue 486 for KCNQ1.



KCNQ1-----PHFMRTN----------------SF>A<EDLDL-------------------------491
KCNQ2---AASRQNSEE----------------AS>L<PGEDI-------------------------517
KCNQ3----YAFWQSSE----------------DA>G<TGDPM-------------------------496
KCNQ4------PRTSAE----------------DA>-<PSEEV-------------------------511
KCNQ5---QPKPVIDAD----------------TA>L<GTDDV-------------------------499
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1TRTEGVIDMRSMSSIDSFISCATDFPEATR>F<SHSP---LTSLP------------SKTGGS619
KCNB2AQTEVIVDMKSTSSIDSFTSCATDFTETER>S<PLPPPSASHLQMKFPTDLPGTEEHQRARGP649
KCNC1-----------------------------C>P<HIDQA-------------------------525
KCNC2-----------------------------S>T<GSEPP-------------------------551
KCNC3-----------------------------C>P<AIDQP-------------------------683
KCNC4-----------------------------G>A<GLTQP-------------------------561
KCND1---TFSEALGAV----------------SP>G<GRT-S-------------------------513
KCND2---VFEESCMEV----------------AT>V<NRPSS-------------------------514
KCND3---MFEQNCMES----------------SM>Q<NYPST-------------------------531
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.A486Tc.1456G>A Putative BenignSIFT:
Polyphen:
p.Ala486Proc.1456G>C UnknownSIFT:
Polyphen: