Paralogue Annotation for KCNQ1 residue 580

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 580
Reference Amino Acid: S - Serine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 580

No paralogue variants have been mapped to residue 580 for KCNQ1.



KCNQ1---------V-----------------SEK>S<KDRGSNTIGARLNRVEDKVTQLDQRLALIT610
KCNQ2KDR--T--KG-----------------PAE>A<ELPEDPSMMGRLGKVEKQVLSMEKKLDFLV641
KCNQ3KHKKSQKGSAFTFPSQQSPRNEPYVARPST>S<EI-EDQSMMGKFVKVERQVQDMGKKLDFLV640
KCNQ4EKG--D--KG-----------------PSD>A<EVVDEISMMGRVVKVEKQVQSIEHKLDLLL637
KCNQ5KSR--E--KI-----------------TAE>H<ETTDDLSMLGRVVKVEKQVQSIESKLDCLL624
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1------------------------------>-<------------------------------
KCNB2------------------------------>-<------------------------------
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1------------------------------>-<------------------------------
KCND2------------------------------>-<------------------------------
KCND3------------------------------>-<------------------------------
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.S580Gc.1738A>G Putative Benignrs200476771SIFT: tolerated
Polyphen: benign