Paralogue Annotation for KCNQ1 residue 641

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 641
Reference Amino Acid: P - Proline
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 641

No paralogue variants have been mapped to residue 641 for KCNQ1.



KCNQ1-----TPGSGGPPREGG--------AHITQ>P<CGSGGS------------------------647
KCNQ2KEPEPAPPYHSPEDSREH---VDRHGCIVK>I<VRSSSSTGQ------------------K--699
KCNQ3--YYPTKGTSSPAEAEK--KEDNRYSDLKT>I<ICNYSETGPPEPP-----------------696
KCNQ4FDPDITSDYHSPVDHEDISVSAQTL-SISR>S<VSTNM-------------------------694
KCNQ5FECEQTSDYQSPVDSKDLSGSAQNSGCLSR>S<TSANISRGLQFILTPNEFSAQTFYALSP--707
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1--------------------TLLDK----->-<------------AVLSPESSIYTTASAKTP734
KCNB2--------------------SQGDR----->-<------------PLLGTEVSAPCQGPSKGL784
KCNC1------------------------------>-<------------------------------
KCNC2------------------------------>-<------------------------------
KCNC3------------------------------>-<------------------------------
KCNC4------------------------------>-<------------------------------
KCND1------------------------------>-<------------------------------
KCND2------------------------------>-<------------------------------
KCND3------------------------------>-<------------------------------
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.P641Lc.1922C>T Putative BenignSIFT: deleterious
Polyphen: benign