Paralogue Annotation for KCNQ1 residue 658

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 658
Reference Amino Acid: T - Threonine
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 658

No paralogue variants have been mapped to residue 658 for KCNQ1.



KCNQ1------------------PELFLPS----N>T<LPTYEQLTVPRRGP-DEGS-----------676
KCNQ2PEGNLRDSDTSISIPSVDHEELERSFSGFS>I<SQSKENLDALNSCY-AAVAPCAK-------829
KCNQ3RRSITRDSDTPLSLMSVNHEELERSPSGFS>I<SQDRDDYVFGPNGG-SS---WMR-------828
KCNQ4------------------------------>-<------------------------------
KCNQ5RKSFDMGGETLLSVCPMVPKDLGKSLSVQN>L<IRSTEELNIQLSGS-ESSGSRGSQDFYPKW864
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1PK---SLPGSTSPKFSTG--TRSEKNHFES>S<PLPTSPKFLRQNCIYSTEAL-TGKGPSGQE829
KCNB2D----SSPNCFADKPSDGRDPLREEGSVGS>S<SPQDTGHNCRQDI-YHAVSE-VKKD-SSQE881
KCNC1------------------------------>-<----------PTEA-VRV------------584
KCNC2------------------------------>-<----------PVTS-PYNSP----------624
KCNC3------------------------------>-<----------ANAA-AWIS-----------756
KCNC4------------------------------>-<----------PTAG-TLFLP----------634
KCND1PA---NT-----PDESQPSSPGGGGRAGST>L<RNSSLGTPCLFPET-VKISS----------646
KCND2PV---TT-----PE--------GDDRPE-->S<P------EYSGGNI-VRVSA----------629
KCND3PA---LT-----PE--------GESRPPPA>S<PGPNTNIPSIASNV-VKVSA----------654
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.T658Nc.1973C>A Putative Benignrs377661455SIFT: tolerated
Polyphen: benign