Paralogue Annotation for KCNQ1 residue 663

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 663
Reference Amino Acid: E - Glutamate
Protein Domain: C-terminus


Paralogue Variants mapped to KCNQ1 residue 663

No paralogue variants have been mapped to residue 663 for KCNQ1.



KCNQ1-------------PELFLPS----NTLPTY>E<QLTVPRRGP-DEGS----------------676
KCNQ2RDSDTSISIPSVDHEELERSFSGFSISQSK>E<NLDALNSCY-AAVAPCAK---------VRP832
KCNQ3RDSDTPLSLMSVNHEELERSPSGFSISQDR>D<DYVFGPNGG-SS---WMR---------EKR831
KCNQ4------------------------------>-<------------------------------
KCNQ5MGGETLLSVCPMVPKDLGKSLSVQNLIRST>E<ELNIQLSGS-ESSGSRGSQDFYPKWRESKL869
KCNA1------------------------------>-<------------------------------
KCNA10------------------------------>-<------------------------------
KCNA2------------------------------>-<------------------------------
KCNA3------------------------------>-<------------------------------
KCNA4------------------------------>-<------------------------------
KCNA5------------------------------>-<------------------------------
KCNA6------------------------------>-<------------------------------
KCNA7------------------------------>-<------------------------------
KCNB1SLPGSTSPKFSTG--TRSEKNHFESSPLPT>S<PKFLRQNCIYSTEAL-TGKGPSGQEKC---831
KCNB2SSPNCFADKPSDGRDPLREEGSVGSSSPQD>T<GHNCRQDI-YHAVSE-VKKD-SSQEGC---883
KCNC1------------------------------>-<-----PTEA-VRV-----------------584
KCNC2------------------------------>-<-----PVTS-PYNSP---------------624
KCNC3------------------------------>-<-----ANAA-AWIS----------------756
KCNC4------------------------------>-<-----PTAG-TLFLP---------------634
KCND1NT-----PDESQPSSPGGGGRAGSTLRNSS>L<GTPCLFPET-VKISS---------------646
KCND2TT-----PE--------GDDRPE--SP--->-<--EYSGGNI-VRVSA---------------629
KCND3LT-----PE--------GESRPPPASPGPN>T<NIPSIASNV-VKVSA---------------654
KCNF1------------------------------>-<------------------------------
KCNG1------------------------------>-<------------------------------
KCNG2------------------------------>-<------------------------------
KCNG3------------------------------>-<------------------------------
KCNG4------------------------------>-<------------------------------
KCNS1------------------------------>-<------------------------------
KCNS2------------------------------>-<------------------------------
KCNS3------------------------------>-<------------------------------
KCNV1------------------------------>-<------------------------------
KCNV2------------------------------>-<------------------------------
cons                              > <                              

See full Alignment of Paralogues


Known Variants in KCNQ1

ProteinCDSDisease ClassificationDiseasedbSNP linksEffect Prediction
p.E663Kc.1987G>A Putative Benignrs375289892SIFT: deleterious
Polyphen: probably damaging