Paralogue Annotation for KCNQ1 residue 92

Residue details

Gene: KCNQ1
Reference Sequences: LRG: LRG_287, Ensembl variant: ENST00000155840 / ENSP00000155840
Amino Acid Position: 92
Reference Amino Acid: S - Serine
Protein Domain: N-terminus

Paralogue Variants mapped to KCNQ1 residue 92

No paralogue variants have been mapped to residue 92 for KCNQ1.

KCNQ1	AAPPVASDL---GPRPPVSL------DPRV>S<IYSTRRPVLARTH-----------------	105
KCNQ2	LS----------KPRAGG--AGAGK-PPKR>N<AFYRK-------------------------	76
KCNQ3	PQ----------GIGL-LAKTPLSRPVKRN>N<AKYRR-------------------------	106
KCNQ4	PLP---------GPGSGSGSACGQR-SSAA>H<KRYRR-------------------------	82
KCNQ5	RMS---------LLGKPL-SYTSSQ-SCRR>N<VKYRR-------------------------	110
KCNA1	PLDMFSEEIKFYELGEEAME----K--FRE>D<EGF---------------------------	136
KCNA10	PIDIFADEISFYELGSEAMD----Q--FRE>D<EGF---------------------------	185
KCNA2	PLDIFSEEIRFYELGEEAME----M--FRE>D<EGY---------------------------	132
KCNA3	PIDIFSEEIRFYQLGEEAME----K--FRE>D<EGF---------------------------	203
KCNA4	PFDIFTEEVKFYQLGEEALL----K--FRE>D<EGF---------------------------	275
KCNA5	SLDVFADEIRFYQLGDEAME----R--FRE>D<EGF---------------------------	219
KCNA6	PLDIFLEEIRFYQLGDEALA----A--FRE>D<EGC---------------------------	140
KCNA7	PLDVFLEEVAFYGLGAAALA----R--LRE>D<EGC---------------------------	112
KCNB1	CALSFSQELDYWGIDEIYLE----S--CCQ>A<RYHQKKEQMNEELKREAE----------T-	154
KCNB2	CALSFGQELDYWGIDEIYLE----S--CCQ>A<RYHQKKEQMNEELRREAE----------T-	158
KCNC1	CGPLYEEELAFWGIDETDVE----P--CCW>M<TYRQHRDAEEALDSFGGAPLDNSADDADAD	137
KCNC2	CGPLFEEELAFWGIDETDVE----P--CCW>M<TYRQHRDAEEALDIFETPDLI-------GG	177
KCNC3	CGPLFEEELGFWGIDETDVE----A--CCW>M<TYRQHRDAEEALDSFEAPDPAGAANAANAA	217
KCNC4	CGPLFEEELTFWGIDETDVE----P--CCW>M<TYRQHRDAEEALDIFESPDG-----GGSGA	171
KCND1	CIQAFDEELAFYGLVPELVG----D--CCL>E<EYRDRKKENAERLAEDEEA-----------	153
KCND2	CISAYDEELAFFGLIPEIIG----D--CCY>E<EYKDRRRENAERLQDDADT-----------	154
KCND3	CISAYDDELAFYGILPEIIG----D--CCY>E<EYKDRKRENAERLMDDNDS-----------	153
KCNF1	CPICFKNEMDFWKVDLKFLD----D--CCK>S<HLSEKREELEEIARRVQL------------	147
KCNG1	CALSFQEELLYWGIAEDHLD----G--CCK>R<RYLQKIEEFAEMVEREEED-----------	186
KCNG2	CALAFRDELAYWGIDEARLE----R--CCL>R<RLRRREEEAAEARAGPTER-----------	140
KCNG3	CELSFYNEMIYWGLEGAHLE----Y--CCQ>R<RLDDRMSDTYTFYSADEPG-----------	133
KCNG4	CALSFQEELAYWGIEEAHLE----R--CCL>R<KLLRKLEELEELAKLHRED-----------	182
KCNS1	CVFAFGQEADYWGLGENALA----A--CCR>A<RYLERRLTQ-PHAWDEDSD---------TP	174
KCNS2	CVFSFSQEIEYWGINEFFID----S--CCS>Y<SYHGRKVEPEQEKWDEQSD---------QE	142
KCNS3	CVFSFCQEIEYWGINELFID----S--CCS>N<RYQERKEENHEKDWDQKSH---------DV	140
KCNV1	CALSFLQEIQYWGIDELSID----S--CCR>D<RYFRRKE-LSETLDFKKD----------T-	171
KCNV2	CPRRFLEELGYWGVRLKYTP----R--CCR>I<CFEERRDELSERLKIQHE------------	219
cons	> <

See full Alignment of Paralogues

Known Variants in KCNQ1

Protein	CDS	Disease Classification	Disease	dbSNP links	Effect Prediction
p.S92P	c.274T>C	Putative Benign			SIFT: Polyphen:
p.S92C	c.275C>G	Unknown			SIFT: deleterious Polyphen: possibly damaging